Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

3354 mxstmucfstmaxdtntcaplets-drgfctsweb

Maximum Strength Mucinex® Fast-Max®
DAY TIME Severe Cold and
NIGHT TIME Cold & Flu Caplets
Drug Facts
Drug Facts (continued)
Active ingredients (in each caplet) Purposes Ask a doctor or pharmacist before use if you are
Mucinex FAST-MAX DAY TIME Severe Cold
■ taking the blood thinning drug warfarin Acetaminophen 325 mg.Pain reliever/fever reducer
■ taking sedatives or tranquilizers (Mucinex FAST-MAX Dextromethorphan HBr 10 mg.Cough suppressant When using this product
Phenylephrine HCl 5 mg.Nasal decongestant ■ do not use more than directed
Active ingredients (in each caplet) Purposes ■ excitability may occur, especially in children (Mucinex
FAST-MAX NIGHT TIME Cold & Flu only) Mucinex FAST-MAX NIGHT TIME Cold & Flu
■ marked drowsiness may occur (Mucinex FAST-MAX NIGHT Acetaminophen 325 mg.Pain reliever/fever reducer
■ alcohol, sedatives, and tranquilizers may increase drowsiness Phenylephrine HCl 5 mg.Nasal decongestant (Mucinex FAST-MAX NIGHT TIME Cold & Flu only) Uses
■ avoid alcoholic drinks (Mucinex FAST-MAX NIGHT TIME ■ temporarily relieves these common cold and flu ■ be careful when driving a motor vehicle or operating (Mucinex FAST-MAX NIGHT TIME Cold & Flu only) ■ cough (Mucinex FAST-MAX DAY TIME Severe Cold only) Stop use and ask a doctor if
■ minor aches and pains ■ headache ■ sore throat ■ nervousness, dizziness, or sleeplessness occur ■ runny nose and sneezing (Mucinex FAST-MAX NIGHT TIME ■ pain, nasal congestion, or cough gets worse, or lasts more ■ helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make ■ fever gets worse, or lasts more than 3 days coughs more productive (Mucinex FAST-MAX DAY TIME ■ new symptoms occur■ cough comes back, or occurs with fever, rash, or headache that lasts. These could be a sign of a serious condition. Warnings
(Mucinex FAST-MAX DAY TIME Severe Cold only) Liver warning: This product contains acetaminophen. Severe
If pregnant or breast-feeding, ask a health professional
■ more than 12 caplets in 24 hours, which is the maximum daily Keep out of reach of children.
Overdose warning: Taking more than the recommended
■ with other drugs that contain acetaminophen dose (overdose) may cause liver damage. In case of overdose, ■ 3 or more alcoholic drinks daily while using this product get medical help or contact a Poison Control Center right Sore throat warning: if sore throat is severe, persists for more
away. Quick medical attention is critical for adults as well as than 2 days, is accompanied or followed by fever, headache, for children even if you do not notice any signs or symptoms.
rash, nausea, or vomiting, consult a doctor promptly.
Do not use
Directions
■ with any other drug containing acetaminophen (prescription ■ do not take more than directed (see Overdose warning)
or nonprescription). If you are not sure whether a drug ■ do not take more than 12 caplets in any 24-hour period contains acetaminophen, ask a doctor or pharmacist.
■ adults and children 12 years of age and older: take 2 caplets ■ with any other drug containing diphenhydramine, even one used on the skin (Mucinex FAST-MAX NIGHT TIME ■ children under 12 years of age: do not use Other information
■ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know Inactive ingredients (Mucinex FAST-MAX
if your prescription drug contains an MAOI, ask a doctor or DAY TIME Severe Cold)
croscarmellose sodium, crospovidone, FD&C Red #40 aluminum lake, FD&C Yellow #6 aluminum lake, magnesium Ask a doctor before use if you have
stearate, microcrystalline cellulose, polyethylene glycol 3350, ■ liver disease ■ heart disease ■ high blood pressure polyvinyl alcohol, povidone, talc, titanium dioxide Inactive ingredients (Mucinex FAST-MAX
■ trouble urinating due to an enlarged prostate gland■ glaucoma (Mucinex FAST-MAX NIGHT TIME Cold & Flu only) NIGHT TIME Cold & Flu)
■ a breathing problem such as emphysema or chronic bronchitis corn starch, croscarmellose sodium, crospovidone, FD&C (Mucinex FAST-MAX NIGHT TIME Cold & Flu only) Blue #1 aluminum lake, hypromellose, magnesium stearate, ■ persistent or chronic cough such as occurs with smoking, microcrystalline cellulose, polydextrose, polyethylene glycol, asthma, chronic bronchitis, or emphysema (Mucinex FAST-MAX povidone, silicon dioxide, stearic acid, titanium dioxide, triacetin DAY TIME Severe Cold only)■ cough that occurs with too much phlegm (mucus) (Mucinex Questions? 1-866-MUCINEX (1-866-682-4639)
FAST-MAX DAY TIME Severe Cold only) You may also report side effects to this phone number.

Source: http://www.mucinex.com/media/115140/mxstmucfstmaxdaytimenighttime_caplets.pdf