Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Class

Root Usual Meaning
Examples
homicide, Homo sapien, hombre, homunculus, personality, impersonate, personify, personalize, nominate, cognomen, ignominious, nomenclature, solar, Sol, solarium, solstice, parasol, solar system… Illuminate, lumen, luminary, illuminant, lunar, Luna, lunacy, lunate, lunar month, lunation… ignite, ignescent, ignition, ignitron, preignition, rebellion, belligerent, rebel, ante-bellum, bellicose, camp, campus, campaign, camporee, champion, annual, annuity, perennial, anno Domini, anniversary, diary, diet, journay, journayman, sojourn, adjourn… congregate, segregation, aggregation, gregarious, Root Usual Meaning
Examples
Corpse, corpulent, corps, corporal, corporeal, … Carnation, carnal, carnivorous, reincarnation, Capital, caption, capricious, precipitate, recapitulation, Nasal, naso, nasofrontal, nostril, post nasal, oral, oration, adoration, exorable, oracle, perorate… dentist, dentine, dentifrice, dent, indent, edentate… vital, vitality, vitamin, vivarium, vivacious, revive… cordial, core, courage, discord, accord, concordance… Article, articulation, articular, articulator, arthritis… Manual, manicure, manikin, amanuensis, manumit, Pedal, pedestrian, pedestal, pedicure, impede, Mortal, mortician, mortification, mortgage, amortize, Root Usual Meaning
Examples
Literary, literate, literal, illiterate, obliterate … Verbal, proverbial, verbiage, verbatim, verbify … Linguist, language, lingo, multilingual, linguistics … Generation, gender, gene, ingenuity, genus, Animal, animation, animadversion, pusillanimous, Judge, jurisprudence, justify, adjudicate, jury, Legislation, legal, legitimate, illicit, delegalize, Civic, city, civilization, civility, civilian, civil Temporary, temporal, contretemps, tempus fugit, Location, locus, allocate, locomotion, relocate, local… Confident, confidant, fiduciary, diffidence, infidel, Crusade, cross, crucifix, crux, excruciate, crucial, Root Usual Meaning
Examples
Benefit, benevolent, benediction, bona fide, Gratitude, gratification, grace, gracious, gratuitous, Belle, belladonna, beau, beautician, belvedere, Malice, malign, malpractice, malicious, malinger, Honest, honorable, dishonor, honorarium, honorary, Sacred, sacrifice, sacrilege, sacrosanct, desecrate, Novelty, innovate, novel, novice, Novocain, Ambient, ambiguous, ambage, ambiguous, ambit, Clarify, clarion, clarinet, claret, declare, declarative… Altitude, exaltation, alto, altimeter, altar… Magnify, magnificent, major, maxim, magniloquent, Gravity, gravitate, gravimetric, aggravate, grieve, Root Usual Meaning
Examples
Question, inquest, inquisitive, questionable, Doctrine, documentary, doctor, indoctrinate, docile, Rational, ration, rationale, rationalize, reason, Science, prescient, conscious, conscience, omniscient, Collect, legible, legend, lectern, lecture, elect… Discern, secretive, discretion, concern, recrement, Recite, citation, excite, incite, cite, recital, recitation… Dictate, dictionary, index, edict, abdication, addict, Eloquent, loquacity, colloquial, ventriloquist, Audience, audible, audiology, audiometer, audition, Notation, notorious, notice, denote, annotation, Script, conscription, scripture, prescription, ascribe, Root Usual Meaning
Examples
Vocal, vociferate, voice, convoke, provocative, Tangent, contagious, tact, intangible, contingent, Video, provident, supervisor, visa, advise, belvedere… Spectator, perspicacity, perspective, specimen, Amble, perambulator, ambage, preamble, preamble, Insomnia, somniloquist, somnambulist, Somnus, Eject, projectile, interject, adjective, trajectory, Donate, donee, date, pardon, condone, donor… Amorous, amicable, amour, inimical, amateur, amicus, Admire, miracle, mirror, miraculous, mirage, Regal, regimen, regalia, regent, regulate, regina… Dominate, dominant, domino, domineer, eminent Root Usual Meaning
Examples
Laboratory, labored (adj.) labor, elaborate, laborious, Transport, portage, purport, importance, portamento, Transfer, circumference, transferee, deference, fertile, Remove, motivation, mobility, motile, mobilize, Transmit, admit, omit, remit, missive, missile, Induce, introduce, deduce, conducive, traduce, Propel, repellent, expel, repulsive, compulsion, push… Fugitive, fleeting, refugee, fugue, fugacious, React, enactment, activities, transact, actuary, agitate… Gradual, graduate, digress, ingredient, egress, Fact, facile facsimile, facilitate, faction, feasible… Turbulent, trouble, turbid, perturb, turbine, Root Usual Meaning
Examples
Clamor, clamant, declamation, claimant, reclamation, Cadence, cascade, decadent, coincide, cadaverous, Closet, closure, recluse, foreclose, claustrophobia, Pressure, express, suppress, depress, repress, Complete, complement, replete, comply, compliment, Capture, incapacitate, captive audience, capsule, Erupt, disrupt, abrupt, corrupt, interrupt, bankrupt… Scissors, concise, precise, homicide, germicide, Cure, accurate, security, curative, curiosity, curator… Revolve, evolve, convolve, revolt, voluminous, Extend, distend, contention, tendon, portend, Complex, plexiglass, plywood, multiply, pliable, Root Usual Meaning
Examples
Tractor, contract, retract, tract, traction, trail.… Strict, stringent, strain, redistrict, stricture, distraught Assault, salient, assail, resilient, salmon, sally, Crescent, crescendo, accrue, crew, concrescence, Current, concurrent, car, corridor, recur, curriculum… Tenant, pretend, pertinacious, tenor, tenet, lietenant… Distort, torture, extort, tortilla, nasturtium, tort… Dissolve, solvent, absolution, soluble, resolve, Fragile, frangible, fraction, frail, refraction, Pendulum, compendium, suspense, propend, Convert, subversion, vertebra, vertigo, versatile, Fluid, influence, affluent, ,fluvial, influx, flush… Root Usual Meaning
Examples
Nature, innate, Natalie, naïve, natality, cognate, Creed, credible, credit, credence, miscreant, recreant, Habitual, habit, inhibit, uninhabitable, habitation, Pleasure, complacency, please, placate, pleasant, Stable, estate, stabilize, statuette, constant, statute, Junction, injunction, adjoin, adjunct, conjunction, Expound, exponent, opponent, postpone, dispose, Recede, intercede, precedent, cede, secede, recession, Convention, convenient, venue, contravene, Sequence, sequential, prosecute, sequacious, Solo, solitaire, solipsism, soliloquy, solifidian, Sediment, sedan, sedation, president, supersede, Root Usual Meaning
Examples
annual, anniversary, perennial, millenium

Source: http://pagefarm.net/ap/vocab11.pdf