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Mode of action and Microbiology
(Cefuroxime (Axetil)) owes its bactericidal activity to the parent
drug Cefuroxime, which is a second-generation cephalosporin. Its
bactericidal action depends on the ability to reach and bind penicillin-
binding proteins located in the bacterial cytoplasmic membrane leading
to inhibition of cell wall synthesis. Cefuroxime is an antibacterial agent
with broad-spectrum activity against a wide variety of pathogens like:
like E.coli, Klebsiella, H.influenza
lactamase producing strains), M.catarrhalis
Penicillinase and non-Penicillinase producing strains). Gram-positive aerobes
(including ß lactamase producing
and others. Gram-negative and Gram-positive anaerobic cocci.
and peptostreptococcus Gram-positive anaerobic bacilli.
Like clostridium speices (except C.
difficile) and propionibacterium
Gram-negative anaerobic bacilli.
Like Bacteroides species ( except B.
fragilis ) and Fusobacterium species.
Under normal renal function, Cefuroxime (Axetil) has a half-life of 1-2hr.
Cefuroxime is widely distributed through out the body and reaches
therapeutic concentrations in most tissues and body fluids including
synovial, pericardial, pleural, and peritoneal fluids. Also bile, sputum,
urine and CSF.
Cefuroxime crosses the placenta and enters breast milk. Indications
Cefutil® is indicated for the treatment of :
1- Upper respiratory tract infections including tonsillopharyngitis, otitis
2- Lower respiratory tract infections including bronchitis, acute
exaserbation bronchitis& pneumoniae.
3- Urinary tract infections and uncomplicated gonorrhea. 4- Skin and soft tissue infections and impetigo.
Dosage and administration
can be given without regard to meals, however, absorption is
tablets and oral suspensions are not bioequivalent, and are
- Patients who can not swallow solids can take Cefuroxime (Axetil)
tablets mixed with fluids (juices or milk). Alternative therapy, such as the oral suspension, should be considered for children.
Usual pediatric dose:
- In children from 3 months up to 2 years 125mg every 12 hours.
- In children over 2 years 250mg every 12 hours.
- Children who can swallow tablets 125-250 mg every 12 hours Usual adult dose
250-500mg every 12 hours.
UTI (Uncomplicated) 125-250mg every 12 hours.
Gonorrhea (Uncomplicated cervical and urethral) 1mg single dose. Use In Pregnancy & Lactation
Pregnancy catergory B, Cefuroxime (Axetil) can be given to pregnant or lactating
women according to physician's assessment. Contraindications
Hypersensitivty to Cefuroxime, any component, or cephalosporins. Precautions
Cross sensitivity: Patients allergic to one cephalosporin, cephamycin, penicillin, or
penicillin derivatives may be allergic to Cefuroxime (Axetil).
Side effects arising from using Cefuroxime Axetil are generally mild and transient in
nature. Like headache, diarrhea, nausea, vomiting, and skin rashes Presentation
F/ C tablets:
Cefuroxime (Axetil) 125mg/tablet (Available in 10 tablets pack ) .
Cefuroxime (Axetil) 250mg/tablet (Available in 10 tablets pack )
Cefuroxime (Axetil) 500mg/tablet (Available in 10 tablets pack ) Cefutil®
Cefuroxime (Axetil) 125mg/ 5 ml (Available in 50 ml pack ). Cefuroxime (Axetil) 250mg/ 5 ml (Available in 50 ml pack ).
DIAGNOSTIC HINTS AND TREATMENT GUIDELINES FOR LYME AND OTHER TICK BORNE ILLNESSES JOSEPH J. BURRASCANO JR., M.D. Fourteenth Edition November, 2002 Copyright, November, 2002 INTRODUCTION Welcome to the fourteenth edition of the “Guidelines.” With the passage of time, our understanding of tick-borne illness has grown, so new information is presented to help u
PVC (Polyvinyl Chloride, also commonly known as ‘vinyl’) is a rigid polymer, possibly most often seen in its ‘natural’ state used as w indow frames. In order to make PVC malleable, a variety of plasticisers are added and other processes are used during manufacture. In particular, this includes the addition of phthalates which provide flexibility, in order to mould and manufacture a wid