Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
Zscomp.pdf
Compositor – Digital Artist
Cell Phone: (323) 528-6501 Email: ziad@polarisfilms.net
849 S. Broadway Loft 406 Los Angeles, CA 90014
Software: Shake, Maya, Nuke, Icy, Digital Fusion, Combustion, Photoshop Knowledge of Unix Command Line, Shake Expressions and Macros Bachelor of Arts - Film Production Emphasis, San Francisco State University 1990 Member of the Visual Effects Society (VES) Rhythm & Hues Studios “The Golden Compass” Feature Film 2007
R&H Comp Sup. Josh Saeta, Lead: Heather Hoyland
Digital Domain “Pirates of the Carribean- At Worlds End” Feature Film 2007
Walt Disney Studios, Director: Gore Verbinski
DD Comp Sup. Sonja Burchard, Comp Lead: Dan Cobbett
“Meet the Robinsons” 3D Stereo – Feature Film Release 2007
Walt Disney Studios, Director: Stephen J. Anderson
DD VFX Supervisor: Nordin Rahhali, Comp Lead: Ryan Phalen
CIS Hollywood “We Are Marshall” Feature Film Release 2006
CIS VFX Supervisor: Tom Smith, VFX Producer: Melissa Brockman
“Fast and Furious: Tokyo Drift” Feature Film Release 2006
Universal Pictures, Original Film, Director: Justin Lin
CIS VFX Supervisor: Gregory Liegey, VFX Producer: Julie Orosz
“Xmen: The Last Stand” Feature Film Release 2006
20th Century Fox, Marvel, Director: Brett Ratner
CIS VFX Supervisor: Bryan Hirota, VFX Producer: Melissa Brockman
“Poseidon” Feature Film Release 2006
Warner Bros., Director: Wolfgang Peterson
CIS VFX Supervisor: Bryan Hirota, VFX Producer: Julie Orosz
“The Reaping” Feature Film Release 2006
Warner Bros., Village Roadshow , Director: Stephen Hopkins
CIS VFX Supervisor: Bryan Hirota, VFX Producer: Lisa Maher
“Fantastic Four” Feature Film Release 2005
CIS VFX Supervisor: Bryan Hirota, VFX Producer: Melissa Brockman
Compositor “The Shaggy Dog” Feature Film Release 2006
Walt Disney Pictures, Director: Brian Robbins
CIS VFX Supervisor: Tom Smith, VFX Producer: Julie Orosz
FLASH FILM WORKS “The Guardian” Feature Film Release 2006
Touchstone Pictures, Director: Andrew Davis
VFX Supervisor: William Mesa, VFX Producer: Emily Wallin
“Zelnorm” Commercial Pharmaceutical “Snow Wonder” Feature Film End Titles
Comp Supervisor: Rob Cribbett, VFX Producer: Sarah Coatts
Compositor “Orange” Commercial Cingular France “Sin City” Feature Film
Miramax/Dimension Films, Quentin Tarantino Sequence
Directors: Frank Miller & Robert Rodriguez
Digital Supervisors: David Lombardi, Everett Burrell, Jeff Goldman
ZOIC STUDIOS Compositor “Serenity” Feature Film
Universal Pictures, Director: Joss Whedon
VFX Producer: Kristen Branan, Comp. Supervisor: Patti Gannon
Compositor “Global Frequency” Television Pilot STAN WINSTON DIGITAL Lead Compositor “Sky Captain and the World of Tomorrow” Feature Film 2004
Paramount Pictures. VFX Supervisor: Andre Bustanoby, Assoc. VFX Supervisor: Jeff Kalmus, VFX Producer: Melissa Brockman
“Because of Win-Dixie” Feature Film 2004
20th Century Fox. Animation Director: Randall Rosa
DIGITAL FILM LABS “Auto Focus” Feature Film 2002 Propaganda Films/ Sony Classics,
Producers: Alicia Allain, Scott Alexander, Pat Dollard, Larry
Karaszewski, Todd Rosken, Director: Paul Schrader
“Willard” Feature Film 2002 New Line Cinema, Hard Eight Pictures
Producers: Richard Brenner, Bill Carraro, Toby Emmerich, Glen
Morgan, James Wong, Director: Glen Morgan
“The Badge” Feature Film 2001
Propaganda Films, Producers: Alicia Allain, Randall Emmett, George Furla,
Rick Hess, Avi Lerner, Trevor Macy, John Morrissey,
MODERN VIDEOFILM Visual Effects Co-Supervisor “Knock Off” Location: Hong Kong Overall
Signature Ent./Sony Studios Producer: Moshe Diamant, Director: Tsui Hark
“Double Team” Location: France, Italy
Mandalay Ent. Sony Studios Producer: Moshe Diamant, Director: Tsui Hark
CRYSTAL SKY VISUAL FX Visual Effects Producer/ “Noah’s Ark” Location: Australia
NBC/ Hallmark Ent. Director: John Irving
PRODUCTION Visual Effects Supervisor “Kindred the Embraced” Location: San Francisco
Visual Effects Co-Supervisor “The Van Helsing Chronicles” Overall “Star Trek Voyager” Paramount Studios Season 2 1995
VFX Producers, Peter Lauritson/ Dan Curry, VFX Supervisors David Stipes/ Joe
“Tales From the Crypt” Silver Pictures/ HBO Seasons 3-5 1991-1993
Producers: Gil Adler, J. Silver, R. Donner, R. Zemeckis, W. Hill
MISSION “To build a world class custom synthesis and contract manufacturing company that uses its own R&D and can deliver products conforming to highest standards of process validation using optimal resources and with equal emphasis on technology, quality, safety with a NO COMPROMISE attitude on ethical, ecological, moral and social values” SYMCHEM serves Pharma