Durante mucho tiempo no había principios uniformes para la Atribución de nombres a los antibióticos https://antibioticos-wiki.es . Más a menudo se les llama por el nombre genérico o especie del producto, con menos frecuencia-de acuerdo con la estructura química. Algunos antibióticos se nombran de acuerdo con el lugar donde se asignó el producto.
Dpm8449hi
CISPLATIN HYDRATION ORIGINATED BY: Pharmacy Clinical Specialist, Oncology APPROVAL:
Medical Director, Cancer Center/Pharmacy & Therapeutics Committee
DISTRIBUTION:
Department Policy Manual ORIGINAL DATE: LAST REVIEWED DATE: SIGNATURE: LAST REVISED DATE:
To provide standardized, evidenced based guidelines for prevention of cisplatin-induced nephrotoxicity.
1. Daily administration regimen refers to any cisplatin regimen that requires administration of a low
dose of cisplatin over multiple days (i.e. 25 mg/m2 daily on days 1-3)
2. > Weekly Administration Regimen refers to any cisplatin regimen that requires administration of
cisplatin on one or multiple days, but given at least one week apart. (i.e. 75 mg/m2 every 21 days,50 mg/m2 days 1 and 8, etc.)
All cisplatin administration cycles will fall into one of two categories: 1. daily administration regimen or 2. $ weekly administration regimen. General administration guidelines pertain to both administration categories. This policy will serve as standard practice guidelines for all patients receiving cisplatin at Hillcrest Hospital following a physicians order. Exceptions include patients enrolled in a clinical trial or other comorbidities (i.e. CHF) that warrant deviation from this policy. 1. Daily Administration Regimen
C Prehydration
B Day 1: Potassium chloride 20meq + Magnesium sulfate 2 grams in 1000ml 0.9% sodium
B Subsequent days: 500 ml 0.9% sodium chloride over 1-2 hours
C Diuretic therapy
B Mannitol: not necessary for low dose, daily therapy B Furosemide (LASIX): not necessary unless patient has signs/symptoms of fluid overload
C Urine output
B Verify that patient has urine output > 100 ml prior to administration of cisplatin
C Post-hydration(optional based on physician preference)
B If yes: 500ml fluid as post hydration over 1-2 hours
P Include IV fluids given with other chemotherapeutic agents (ex: Drug A in 500 ml of
0.9% sodium chloride over 2 hours after cisplatin administration).
B Instruct patient to drink 1-2 liters of fluid per day for 2-3 days following cisplatin
2. > Weekly Administration Regimen
C Prehydration
B Potassium chloride 20meq + Magnesium sulfate 2 grams in 1000ml 0.9% sodium chloride
C Diuretic therapy
B Mannitol: Current literature does not support the use of Mannitol to prevent Cisplatin-induced
nephrotoxicity. However, 12.5g may be given, based on physician preference.
B Furosemide (LASIX): not necessary unless patient has signs/symptoms of fluid overload
C Urine output
B Verify that patient has urine output > 200 ml prior to administration of cisplatin
C Post-hydration
B Post hydration consist of 1000 ml IV fluid.
P Include IV fluids given with other chemotherapeutic agents.
B Instruct patient to drink 1-2 liters of fluid per day for 2-3 days following cisplatin
3. General Administration Guidelines
C Electrolyte levels should be monitored and additional supplementation should be added as
C Co-administration of other nephrotoxic agents should be avoided whenever possible
B Including, but not limited to: aminoglycosides, non-steroidal anti-inflammatory drugs
(NSAIDS), iodinated contrast media, and bisphosphonates
Al-Sarraf M, Fletcher W, Oishi N, Pugh R, et.al. Cisplatin hydration with and without mannitoldiuresis in refractory disseminated malignant melanoma: a southwest oncology group study. CancerTreatment Reports 66(1):31-35, 1982.
Goodman M. Cisplatin: outpatient and office hydration regimens. Seminars in Oncology Nursing3(1):36-45, 1987.
Hodgkinson E. Neville-Webbe HL, Coleman RE. Magnesium depletion in patients receiving cisplatin-based chemotherapy. Clinical Oncology 18:710-718, 2006.
Launay-Vacher V, Rey JB, Isnard-Bagnis C, Deray G, Daouphars M. Prevention of cisplatinnephrotoxicity: state of the art recommendations from the European Society of Clinical PharmacySpecial Interest Group on Cancer Care. Cancer Chemother Pharmacol 61:903-909, 2008.
Numico G, Benasso M, Vannozzi, M, et. al. Hydration regimen and hematological toxicity of acisplatin-based chemotherapy regimen. Anticancer Research 18:1313-1318, 1998.
Ostrow S, Egorin MJ, Hahn D, et.al. High-dose cisplatin therapy using mannitol versus furosemidediuresis: comparative pharmacokinetics and toxicity. Cancer treatment reports 65(1-2):73-78, 1981.
Portilla D, Safar AM, Kundi IK, et. al. Cisplatin-induced nephrotoxicity. Uptodate version 16.1. January 31,2008. www.uptodateonline.com. Accessed on 05/30/2008.
Tiseo M, Martell O, Mancuso A, et.al. Short hydration regimen and nephrotoxicity of intermediate tohigh-dose cisplatin-based chemotherapy for outpatient treatment in lung cancer and mespthelioma. Tumori 93:138-144, 2007.
Santoso JT, Lucci JA, Coleman RL, et. al. Saline, mannitol, and furosemide hydration in acutecisplatin nephrotoxicity: a randomized trial 52:13-18, 2003.
“Truth” includes evidence, E , a part of relative to evidence, P (H,E), and the utility of actions, U (A,E), Who selects investigator, analyst and writer? Who decides whether to submit to publish? Who possesses clinical trial data and at whose “Who has exclusive discretion over design and conduct of experiment? who selects the investigator, analyst, and writer? who has
In an effort to promote the appropriate use of certain drugs and to help better manage the cost of expensive drugs, the ConnectiCare Pharmacy & Therapeutics Committee has developed a list of prescription drugs that require prior authorization. Prior authorization requests must be faxed to ConnectiCare’s Pharmacy Services department at 860-674-2851 or toll free 800-249-1367 by the prescribin