publications

Publications
1. Tornatore KM, Morse GD, Jusko WJ, Walshe JJ: Methylprednisolone Disposition in Renal Transplant Recipients Receiving Triple Drug Immunosuppression. Transplantation, 1989;48:962-965.
2. Tornatore KM, Reed KA, Venuto RC: Racial Differences in Pharmacokinetics of Methylprednisolone in Black and White Renal Transplant Recipients. Pharmacother 1993;13:481-486.
3. Tornatore KM, Logue G, Venuto RC, Davis DJ: Methylprednisolone Pharmacokinetics in Elderly and Young Healthy Males. J Am Geriatr Soc 1994;42:118-122.
4. Tornatore KM, Biocevich D, Reed KA, Tousley K, Singh P, Venuto R: Methylprednisolone Pharmacokinetics, Cortisol Response, and Adverse Effects in Black and White Renal Transplant Recipients. Transplantation 1995;59:729-736. 5. Tornatore KM, Reed KA, Venuto RC: Pharmacokinetics of Methylprednisolone During Acute Renal Al ograft Rejection. Clin Transplantation 1995;9:74-78. 6. Tornatore KM, Biocevich D, Reed K, Tousley K, Gray V, Singh J, Venuto R: Post- transplant Diabetes Mel itus and Methylprednisolone Pharmacokinetics in Black and White Renal Transplant Recipients. Clin Transplantation 1995;9:289-296. 7. Tornatore KM, Reed K, Venuto RC: 24 Hour Assessment of CD4+ and CD8+ Lymphocytes in Renal Transplant Recipients Receiving Chronic Methylprednisolone. Clin. Nephrol 1995;44:290-298.
8. Tornatore KM, Reed KA, Venuto RC: Assessment of Methylprednisolone Pharmacokinetics and Cortisol Response During Early and Chronic Postrenal-Transplant Periods. Transplantation 1995;60:1607-1611.
9. Tornatore KM, Logue G, Venuto RC, Davis PJ: Cortisol Pharmacodynamics after Methylprednisolone Administration in Young and Elderly Males. J. Clinical Pharmacol 1997;37:304-311.
10. Tornatore KM, Venuto RC, Logue G, Davis PJ: CD4+ and CD8+ Lymphocyte and Cortisol Response Patterns in Elderly and Young Males During Methylprednisolone Exposure. J. of Medicine 1998;29(3-4):159-183.
11. Frerichs VA, Tornatore KM. Determination of the Corticosteroids Prednisone, Prednisolone, Dexamethasone, and Cortisol in Human Serum and Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry. Journal of Chromatography B 2003;802:329-338.
12. Tornatore KM, Gil iland KA, Farooqui M, Reed KA, Venuto RC. Pharmacokinetics and Pharmacodynamics of Methylprednisolone in Premenopausal Renal Transplant Recipients. J. Clinical Pharmacol. 2004; 44:9:1003-1011.
13. Qazi YA, Forrest A, Tornatore K, Venuto R. The Clinical Impact of 1:1 Conversion from Neoral to Generic Cyclosporine (Gengraft) in Renal Transplant Recipients with Stable Graft Function. Clinical Transplantation 2006; 20:313-317.
14. DiFrancesco R , Frerichs V, Donnel y J, Hagler C, Hochreitter J, Tornatore KM. Simultaneous Determination of Cortisol, Dexamethasone, Methylprednisolone, Prednisone, Prednisolone, Mycophenolic Acid and Mycophenolic Acid Glucuronide in Human Plasma Utilizing Liquid Chromatography Tandem Mass Spectrometry. Journal of Chromatography B. 2007:859:42-51. 15. Nainani N, Singh N, Shanahan T, Damodar A, Parimoo N, Ummadi S, Qazi Y, Murray BM, Tornatore KM, Ciccirella JC, Blessios GA, Venuto RC. Cross Reactive Epitope Group Antibodies in Sensitized Kidneys Transplant recipients was associated with Early Acute Antibody Mediated Rejection. Transplant Immunology (in press 12/08) Published Abstracts: (Selected)
1. T ornatore KM , Gil iland KK, Ciminel i AM, Reed KA, Farooqui M, Venuto RC. The influence of gender on the pharmacokinetics and cortisol response of glucocorticoids in renal transplant recipients. Transplantation 1999;27:7. 2. T ornatore KM , Hom J, Reed KA, Fountaine R, Venuto RC. Radiologic and biochemical correlates of steroid-induced bone changes in female renal transplant recipients. Transplantation 1999;27:7. 3. F ountaine R, Tornatore KM, Gil iland KK, Ciminelli AM, Hom J, Venuto RC Glucocorticoid Pharmacokinetics and Osteoporosis in Female Renal Transplant Recipients. Clin. Pharmacol. Ther. 2000; 67:2 p. 109 (Abstract # PI-79) 4. T ornatore KM , Fountaine R, Hom J, Reed KA, Venuto R. Post-Transplant Osteoporosis in Relationship to Glucocorticoid Pharmacology. Transplantation 69:8; Supplement April 27, 2000; p. 5324 (Abstract # 816) 5. T ornatore KM , Fountaine R, Hom J, Reed KA, Venuto R. Treatment of Post- Transplant Osteoporosis in Female Patients With Intranasal Calcitonin. Transplantation 69:8, Supplement April 27, 2000; p 5288 (Abstract #679) 6. T ornatore KM , Fountaine RJ, Hom J, Reed KA, Venuto RC. Post-Transplant Osteoporosis and Assessment of Transforming Growth Factor-β(TGF-β) in Female Renal Transplant Recipients (RTR). J Am Soc Nephrol 2000;11: September 2000; p 726A ( Abstract #A3820) 7. T ornatore KM , Fountaine R, Hom J, Reed KA, Venuto R. Treatment of Post- Transplant Osteoporosis in Female Patients with Intranasal Calcitonin. Pharmacotherapy 2000;20 (2) : p 625A ( Abstract #176 encore) 8. T ornatore KM , Fountaine R, Hom J, DeFrancesco R, Venuto R. Assessment of Tumor Necrosis Factor-α in Post-transplant Osteoporosis in Female Renal Transplant Recipients. American Journal of Transplantation 2001 1:Supplement 1; page 294 (Abstract #631) 9. T ornatore KM , Bashir K, Schoehn M, Hom J, Murray BM, Venuto LM, Venuto RC. Use of Therapeutic Drug Monitoring to Evaluate Rapamycin Dosing Regimens in Renal Transplant Recipients. American Journal of Transplantation 2001 1:Supplement 1; page 294 ( Abstract #644) 10. Tornatore KM, Fountaine RJ, Gil iland KA, Hom J, Reed KA, Venuto RC. Influence of Gonadal Hormones and Steroid Kinetics on Post-Transplant Osteoporosis. J Am Soc Nephrol, 12:2001; page 949A (Abstract #A4960) 11. T ornatore KM , Farooqui M, Singh P, Biocevich D, Ciminel i-Rubino A, Gil iland K, Forrest A, Coutu S, Venuto R. Gender Differences of Glucocorticoid Pharmacodynamics in Renal Transplant Recipients. J Am Soc Nephrol 2002:13; page 183A ( Abstract # F-PO610).
uazi YA , Forrest A, Tornatore KM, Schoenl M, Blas SD, Venuto RC. The Clinical and Economic Impact of 1:1 Conversion from Neoral to Gengraft. J Am Soc Nephrol 2002:13; page 366A (Abstract # SA-PO505).
16. T ornatore KM , Somervil e T, Smith LD, DiFrancesco R, Shihab F, Woodle S. Interpatient Variability in Prednisolone Pharmacokinetics and Cortisol Pharmacodynamics Prior to Steroid Withdrawal. J Am Soc Nephrol 2003; 14:647A (Abstract #SU-PO519).
il is KA , Dole K, Yassa S, Leca N, Venuto RC, Tornatore KM. Racial Comparison of T Lymphocyte Populations and T Regulatory Cel Pharmacodynamics during Chronic Immunosuppression. J Am Soc Nephrol 2004; 15:293A (Abstract # F-PO1042).
18. T ornatore, KM , Brazeau D, Dole K, Gil is KA, Lecca N, Yassa S, Venuto RC. Time- Dependent Expression of MDR-1 in Stable Renal Transplant Recipients. Clin. Pharmacol.Ther. 2005:72( PII-43).
il is KA , Quazi Q, Karam,J, Blessios G, Venuto R, Tornatore K. Serial Pharmacodynamic Responses to Anti-lymphocyte Globulin. J. American Soc. Nephrology 2005:16 (#TH-PO543).
20. Tornatore KM, Dole K, Brazeau D, Gil is K, Zack J, Lecca N, Yassa S, Venuto R,. Race and Genotype Influence on Pharmacokinetics of Cyclosporine. J. American Soc. Nephrology 2005:16 (#SA-PO636).
. M. Tornatore , Pharm.D., K. A. Gil is, Pharm.D., K. Dole, Pharm.D., N. Leca, M.D., S. Yassa, M.D., P. Wal ace, Ph.D., R. C. Venuto, M.D. Pharmacokinetic Factors Associated with Temporal Pharmacodynamics of T regulatory lymphocytes (Tregs) during Immunosuppressive Therapy (IT) . Clin. Pharmacol.Ther. 2006:79:2( PI-54).
22. T ornatore KM , Gil is KA, Dole K, Wal ace P, Leca N, Wilding G, Venuto RC. Time Dependent Change in Intracel ular cytokines in African Americans and Caucasian Renal Transplant Recipients. Amer. J. Transplantation 2006:6: 141 (Abstract 23. T ornatore KM , Brazeau D, Wilding G, Dole K,Venuto RC; Integration of Drug Transporter Expression and Metabolic Genotypes with Cyclosporine(CYA) Pharmacokinetics(PK) in Renal Transplant recipients (RTR); J Am Soc Nephrol. 2006:17:564A ( Abstract F-PO1085) 24. Tornatore, KM, Brazeau D, Dole K, Gil is KA, Lecca N, Yassa S, Venuto RC. Impact of Gender, Race and Time on MDR-1 Gene Expression in Stable Renal Transplant Recipients. Clin. Pharmacol.Ther. 2007:81:2(Poster).
kusanya O.O , Dole K, Zack J, Forrest A, Gundroo A, Leca N, Venuto RC, Tornatore KM. Population Pharmacokinetic Model of Mycophenolic Acid and its Metabolite-Mycophenolic Acid Glucuronide in Long Term Renal Transplant Patients using Monte CArlo Parametric Expectation Maximization. Clin. Pharmacol.Ther. 2007:81:2 (Poster).
udchada P, Dole K., Leca N, Gundroo A, Venuto RC, Tornatore KM. Influence of Race and Steroid Use on Mycophenolic Acid Pharamcokinetics Post- Renal Transplant . Clin. Pharmacol. Ther. 2007:81:2 (Poster).
udchada P , Dole K, Zack J, Leca N, Gundroo A, Venuto RC, Tornatore KM. Influence of race, steroid use and Renal function on Mycophenolic Acid Pharmacokinetics in Renal Transplant Recipients. Amer. J. Transplant. 2007:7:2:449.(Poster-#1172) udchada P , Dole K, Zack J, Leca N, Gundroo A,, Venuto RC, Tornatore KM. Influence of Steroid Use and Gender on Mycophenolic Acid Pharmacokinetics Post-Renal Transplant. Amer. J. Transplant. 2007:7:2:450.(Poster-#1179) 29. Qazi, Y, Singh N, Gundroo A, Khalil F, Hassan M, Murray B, Blessios G, Tornatore K, Venuto RC. One year Results of Alemtuzumab Induction, Calcineurin Minimization Protocol in Renal Transplant Recipients Monitored by Surveil ance Biopsies. Amer. J. Transplant. 2007:7:2:444.(Poster-#1159) ingh N , Gundroo A, Murray B, Qazi, Y, Hassan M, Khalil F, Blessios G, Tornatore K, Venuto RC. Maintenance Steroid Free CAmpath-1H Induction Regimen Reduces Metabolic Complications. Amer. J. Transplant. 2007:7:2:522.(Poster-#1458) 31. Singh N, Murray B, Gundroo A, Qazi, Y, Hassan M, Khalil F, Blessios G, Tornatore K, Venuto RC.Impact of Campath-H Induction on CMV Infection in Renal Transplant Recipients. Amer. J. Transplant. 2007:7:2:522.(Poster-#1459) 32. T ornatore KM , Dole K, Zack J, DeFrancesco R, Gil is K, Leca N, Gundroo A, Venuto RC. Cyclosporine Gender Differences with 12 hour Pharmacokinetic Analysis in Stable Renal Al ograft Recipients. J Am Soc Nephrol ; November 2, 2007 (PO-612) 33. Singh N, Nainani N, Qazi, Y, Murray B, Gundroo A, Blessions G, Tornatore K, Venuto, R: Outcomes of Alemtuzumab Induction in High Risk Renal Transplant Recipients. . J Am Soc Nephrol ; November 2, 2007 (PO-636).
udchada P, Brazeau,D, Dole K.,Venuto RC, Tornatore KM; Quantitative real-time PCR Analysis of MRP-2 Expression in Peripheral Mononuclear Cel s: Clin. Pharmacol.Ther. 2008:82:3 (Poster).
udchada P, Gundroo A, Donneally J, DeFrancesco R, Hochreiter J, Venuto R, Tornatore KM: Influence of Cyclosporine Exposure on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients. Amer. J. Transplant. 2008:8:5.
(Abstract #1562-Poster) 36. Nainani N, Patel N,Rahman M, Tahir N, Murray B, Gundroo A, Blessions, G, Tornatore, K , Venuto R; Effect of Steroid Free Maintenance Immunosuppression Protocol on Progression of Chronic Al ograft Nephropathy; Amer. J. Transplant. 2008:8:2.(Abstract #457-Platform) 37. Patel N, Nainani N, Murray, BM, Gundroo A, Blessions, G,Tornatore, KM, Venuto, RC. Effect of Steroid Avoidance and Low Dose Calcinuerin-Inhibitor Immunosuppression on Progression of Chronic Al ograft Nephropathy (CAN) Assessed by Surveil ance Biopsy. . J Am Soc Nephrol 2008;19: November 2008. (Poster-SA-PO2571) 38. Tornatore KM, Sudchada P,Brazea DA,Venuto RC. Time Dependent Expression of MRP-2 in Periperhal Mononuclear Cel s in African American and Caucasian Renal
Transplant Recipients. Clin. Pharmacol.Ther. 2009: (Poster: PIII-25)
39. Tornatore KM, DiFrancesco R, Sudchada P, Gundroo A, Minderman H, O'Loughlin K, Wilding G, Danison R,Venuto RC, Assessment of P-glycoprotein in Peripheral
Mononuclear cel s in African American and Caucasian Renal Transplant Recipients
During Chronic cyclosporine Therapy. Clin. Pharmacol.Ther. 2009: (Poster: PIII-24)
GRANT SUPPORT
“Time-dependent MRP-2 Expression in Peripheral Mononuclear Cel s in Stable African American and Caucasian Renal Transplant Recipients receiving Neoral® (Cyclosporine) and Myfortic® (Mycophenolic Acid)” - A supplemental study to Protocol CERL080A-US56 The Relationship of Drug Exposure and Immunodynamic Responses during Cel Cept® conversion to Myfortic® in Stable African American and Caucasians Renal Transplant Recipients; Protocol CERL080A-US56; Novartis-Investigator Initiative; Principal investigator, January 2007-December 2008 “The Relationship of 2 hour Cyclosporine Concentrations, Race and Gender in Long-term Renal Transplant Recipients”, Novartis-Investigator Initiative; Principal investigator, 12/2003-7/2007 1. “Influence of Race on Immunosuppressive Pharmacology and Immune Response during Transplantation”, Interdisciplinary Research and Creative Activities Fund ( IRCAF) from University at Buffalo, Principal investigator, 3/2003-3/2005 2. “Genetic Factors Influencing Drug Responses in Renal Transplant Recipients”, Western New York Kidney Foundation/UNYTS, Principal Investigator, 11/1/2002 3. “Glucocorticoid Pharmacokinetics During Rapid Steroid Withdrawal and Prolonged Steroid Immunosuppression in Renal Transplant Recipients”- Sub-study to Fujisawa Protocol #20-99-001: A Prospective, Randomized, Multicenter Double-Blind Study of Early Corticosteroid Double Blind Cessation vs. Long Term Maintenance Corticosteroid Therapy With Zenapax, Prograf, and Cel Cept in Primary Renal Transplant Recipients; Fujisawa; Principal Investigator; 4. “Outcomes Assessment of Steroid-induced Osteoporosis in Male Renal Transplant Recipients” Western New York Kidney Foundation/UNYTS, Principal Investigator , 6/1/2001 to 5/30/2002 5. “Clinical Outcomes Assessment of Post-transplant Osteoporosis in Female Renal Transplant Recipients” Western New York Kidney Foundation/UNYTS, Principal investigator; 6/1/2000 to 5/30/2001 6. "The Influence of Race and Gender on Pharmacokinetics and Pharmacodynamics of Methylprednisolone in Renal Transplant Recipients" Upjohn, Principal investigator; 2/96-6/01 7. “Innovative Outcomes Assessment in Steroid-Induced Osteoporosis after Renal Transplantation”, Western New York Kidney Foundation/UNYTS, Principal Investigator 5/1/1999 to 4/30/2000 8. “Management of glucocorticoid-induced osteoporosis with intranasal calcitonin in renal transplant patients” awarded from Research for Health, Erie County 1/98-6/99 Co-investigator 9. "Racial and Gender Effects on the Pharmacokinetics and Pharmacodynamics of Methylprednisolone in Elderly and Renal Transplant Recipients", Upjohn; Principal Investigator, 8/93-8/97 10.“24-hour cytokine profiles in stable renal transplant recipients” awarded from UB Kapoor Foundation, Principal Investigator, 8/97 11.“Ganciclovir pharmacokinetics in renal transplant recipients” Research For Health, Erie County 1/97–12/97; Co-investigator 12."Pharmacokinetic and Pharmacodynamic Evaluation of Methylprednisolone in Renal Transplant Recipients", Upjohn; Principal Investigator ; 2/92 - 2/95 13."Pharmacokinetic and Pharmacodynamic Evaluation of Methylprednisolone in Elderly", Upjohn; Principal Investigator, 1/91 and 2/92 14. "Pharmacokinetic Evaluation of Methylprednisolone in Renal Transplant Recipients", National Kidney Foundation of Western New York; Principal Investigator , 2/91 15. "Pharmacokinetic and Pharmacodynamic Evaluation of Methylprednisolone in Healthy Elderly", Upjohn; Principal Investigator, 2/90. 16. "Pharmacokinetic and Pharmacodynamic Evaluation of Methylprednisolone in Renal Transplant Recipients", Upjohn; Principal Investigator, 2/90. 17."Pharmacokinetic and Pharmacodynamic Evaluation of Methylprednisolone in Healthy Elderly", Upjohn, Principal Investigator, 12/88. 18. "Pharmacokinetics of Methylprednisolone in Renal Transplant Recipients", Upjohn; Principal Investigator; 12/88.
19. "Pharmacokinetics of Methylprednisolone in Healthy Elderly", Upjohn; Principal 20. "Clinical Evaluation of Cyclosporine-Methylprednisolone Pharmacokinetic Inter- action in Renal Transplantation", Sandoz, Co-investigator, 11/85. POST DOCTORAL FELLOWSHIP/RESIDENT
2001-2002
2003.2004
2006-2008 Patcharaporn Sudchada, Pharm.D. Clinical Pharmacology - International

Source: http://prc.buffalo.edu/ImmunosuppreREsearchProgram109.pdf