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MATERIAL SAFETY DATA SHEET
Bayer MaterialScience LLC
TRANSPORTATION EMERGENCY
Product Safety & Regulatory Affairs
100 Bayer Road
Pittsburgh, PA 15205-9741
NON-TRANSPORTATION
1. Product and Company Identification

Product Name:
Material Number:
Chemical Family:
Aliphatic Polyisocyanate Based on Isophorone Diisocyanate (IPDI) 2. Hazards Identification
Emergency Overview

DANGER! Color: Light yellow Form: liquid viscous Odor: Slight.
Toxic gases/fumes may be given off during burning or thermal decomposition. Closed container may forcibly rupture under extreme heat or when contents have been contaminated with water. Use cold water spray to cool fire-exposed containers to minimize the risk of rupture. Causes respiratory tract irritation. May cause allergic respiratory reaction. Harmful if inhaled. Respiratory sensitizer. Lung damage and respiratory sensitization may be permanent. Causes skin irritation. May cause allergic skin reaction. Skin sensitizer. Animal tests and other research indicate that skin contact with diisocyanates can play a role in causing isocyanate sensitization and respiratory reaction. Causes eye irritation. May cause lung damage.
Potential Health Effects

Primary Routes of Entry:

Medical Conditions Aggravated by
Skin Allergies, Eczema, Asthma, Respiratory disorders Exposure:

HUMAN EFFECTS AND SYMPTOMS OF OVEREXPOSURE
Inhalation

Acute Inhalation
For Product: DESMODUR VPLS 2371
Diisocyanate vapors or mist at concentrations above the TLV or PEL can irritate (burning sensation) the
mucous membranes in the respiratory tract (nose, throat, lungs) causing runny nose, sore throat, coughing,
chest discomfort, shortness of breath and reduced lung function (breathing obstruction). Persons with a
preexisting, nonspecific bronchial hyperreactivity can respond to concentrations below the TLV or PEL
with similar symptoms as well as asthma attack or asthma-like symptoms. Exposure well above the TLV
or PEL may lead to bronchitis, bronchial spasm and pulmonary edema (fluid in lungs). Chemical or
hypersensitivity pneumonitis, with flu-like symptoms (e.g., fever, chills), has also been reported. These
symptoms can be delayed up to several hours after exposure. These effects are usually reversible.
For Component: Benzoyl Chloride
Expected to be toxic by inhalation. Causes respiratory tract irritation with symptoms of coughing, sore
throat and runny nose. May cause nervous system effects which can include symptoms of dizziness,
incoordination, headache, numbness, and/or confusion.
Chronic Inhalation
For Product: DESMODUR VPLS 2371
As a result of previous repeated overexposures or a single large dose, certain individuals may develop
sensitization to diisocyanates (asthma or asthma-like symptoms) that may cause them to react to a later
exposure to diisocyanates at levels well below the TLV or PEL. These symptoms, which can include chest
tightness, wheezing, cough, shortness of breath or asthmatic attack, could be immediate or delayed up to
several hours after exposure. Extreme asthmatic reactions can be life threatening. Similar to many non-
specific asthmatic responses, there are reports that once sensitized an individual can experience these
symptoms upon exposure to dust, cold air or other irritants. This increased lung sensitivity can persist for
weeks and in severe cases for several years. Sensitization can be permanent. Chronic overexposure to
diisocyanates has also been reported to cause lung damage (including fibrosis, decrease in lung function)
that may be permanent.
For Component: Benzoyl Chloride
Prolonged or repeated exposure may result in adverse respiratory effects including cough, tightness of chest
and shortness of breath. May cause kidney damage. May cause liver damage.
Skin
Acute Skin
For Product: DESMODUR VPLS 2371
Causes irritation with symptoms of reddening, itching, and swelling. Can cause sensitization. Persons
previously sensitized can experience allergic skin reaction with symptoms of reddening, itching, swelling,
and rash. Cured material is difficult to remove.
For Component: Benzoyl Chloride
Corrosive with symptoms of reddening, itching, swelling, burning and possible permanent damage. Toxic
by skin absorption. May cause allergic skin reaction with symptoms of reddening, itching, swelling, and
rash.
Chronic Skin
For Product: DESMODUR VPLS 2371
Potent skin sensitizer. Once sensitized , an individual may react to direct skin contact or even to airborne
levels below the TLV with reddening, swelling, rash and in severe cases blistering and hives. These
symptoms may be immediate or delayed several hours. Animal tests and other research indicate that skin
contact with diisocyanates can play a role in causing isocyanate sensitization and respiratory reaction. This
data reinforces the need to prevent direct skin contact with isocyanates.
For Component: Benzoyl Chloride
Chronic exposure may cause symptoms similar to those described in chronic inhalation.
Eye
Acute Eye
For Product: DESMODUR VPLS 2371
Causes irritation with symptoms of reddening, tearing, stinging, and swelling. May cause temporary
corneal injury. Vapor may cause irritation with symptoms of burning and tearing.
For Component: Benzoyl Chloride
Corrosive with symptoms of reddening, tearing, swelling, burning and possible permanent damage.
Chronic Eye
For Product: DESMODUR VPLS 2371
Prolonged vapor contact may cause conjunctivitis.
For Component: Benzoyl Chloride
Prolonged vapor contact may cause conjunctivitis.
Ingestion
Acute Ingestion
For Product: DESMODUR VPLS 2371
May cause irritation; Symptoms may include abdominal pain, nausea, vomiting, and diarrhea.
For Component: Benzoyl Chloride
Slightly toxic by ingestion. Corrosive to the digestive tract with symptoms of burning and ulceration. May
cause nervous system effects which can include symptoms of dizziness, incoordination, headache,
numbness, and/or confusion.
Chronic Ingestion
For Component: Benzoyl Chloride
May cause kidney damage. May cause liver damage.
Carcinogenicity:
IARC - Overall evaluation: 2A Probable carcinogen.
3. Composition/Information on Ingredients

Hazardous Components
Weight %
Components
4. First Aid Measures

Eye Contact
In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Use lukewarm water
if possible. Use fingers to ensure that eyelids are separated and that the eye is being irrigated. Then remove
contact lenses, if easily removable, and continue eye irrigation for not less than 15 minutes. Get medical
attention.
Skin Contact
Immediately remove contaminated clothing and shoes. In case of skin contact, wash affected areas with
soap and water. Use lukewarm water if possible. After washing, cover affected skin area with polyethylene
glycol (300-500 molecular weight) and wash again immediately with soap and water to thoroughly remove
polyethylene glycol and residual isocyanate. Repeat if necessary. Get medical attention immediately. Wash
contaminated clothing before reuse.
Inhalation
Move to an area free from further exposure. Get medical attention immediately. Administer oxygen or
artificial respiration as needed. Asthmatic symptoms may develop and may be immediate or delayed up to
several hours. Extreme asthmatic reactions can be life threatening.
Ingestion
Do not induce vomiting. Wash mouth out with water. Do not give anything by mouth to an unconscious
person. Get medical attention.
Notes to physician
Eyes: Stain for evidence of corneal injury. If cornea is burned, instill antibiotic/steroid preparation as
needed. Workplace vapors could produce reversible corneal epithelial edema impairing vision. Skin: This
compound is a skin sensitizer. Treat symptomatically as for contact dermatitis or thermal burn. Ingestion:
Treat symptomatically. There is no specific antidote. Inducing vomiting is contraindicated because of the
irritating nature of the compound. Inhalation: Treatment is essentially symptomatic. An individual having
a dermal or pulmonary sensitization reaction to this material should be removed from further exposure to
any diisocyanate.
5. Fire-Fighting Measures

Suitable Extinguishing Media:
dry chemical, carbon dioxide (CO2), foam, water spray for large fires.
Special Fire Fighting Procedures
Firefighters should wear NFPA compliant structural firefighting protective equipment, including self-
contained breathing apparatus and NFPA compliant helmet, hood, boots and gloves. Avoid contact with
product. Decontaminate equipment and protective clothing prior to reuse. During a fire, isocyanate vapors
and other irritating, highly toxic gases may be generated by thermal decomposition or combustion.
Exposure to heated diisocyanate can be extremely dangerous.
Unusual Fire/Explosion Hazards
Closed container may forcibly rupture under extreme heat or when contents are contaminated with water
(CO2 formed). Use cold-water spray to cool fire-exposed containers to minimize the risk of rupture. Large
fires can be extinguished with large volumes of water applied from a safe distance, since reaction between
water and hot diisocyanate can be vigorous.
6. Accidental release measures

Spill and Leak Procedures
Evacuate non-emergency personnel. Isolate the area and prevent access. Remove ignition sources. Notify
management. Put on protective equipment. Control source of the leak. Ventilate. Contain the spill to
prevent spread into drains, sewers, water supplies, or soil. Call Bayer at 412-923-1800 for assistance and
advice. Major Spill or Leak (Standing liquid): To minimize vapor, cover the spillage with fire fighting
foam (AFFF). Released material may be pumped into closed, but not sealed, metal container for disposal.
Process can generate heat. Minor Spill or Leak (Wet surface): Cover spill area with suitable absorbent
material (Kitty Litter, Oil-Dri®, etc). Saturate absorbent material with neutralization solution and mix.
Wait 15 minutes. Collect material in open-head metal containers. Repeat applications of decontamination
solution, with scrubbing, followed by absorbent until the surface is decontaminated. Check for residual
surface contamination. Swype® test kits have been used for this purpose. Apply lid loosely and allow
containers to vent for 72 hours to let carbon dioxide (CO2) escape.
Additional Spill Procedures/Neutralization
Neutralization solution: mix equal amounts of the following to total two times the estimated spill volume:
(1) mineral spirits 80%, VM&P naphtha 15% and household detergent 5%; and (2) a 50/50 mixture of
monoethanolamine and water. Bayer requires that CHEMTREC be immediately notified (800-424-9300) when this product is unintentionally released from its container during its course of distribution, regardless of the amount released. Distribution includes transportation, storage incidental to transportation, loading and unloading. Such notification must be immediate and made by the person having knowledge of the release. 7. Handling and Storage

Storage Period
6 Months @ 25 °C (77 °F)
Handling/Storage Precautions
Do not breathe vapors, mists, or dusts. Use adequate ventilation to keep airborne isocyanate levels below
the exposure limits. Wear respiratory protection if material is heated, sprayed, used in a confined space, or
if the exposure limit is exceeded. Warning properties (irritation of the eyes, nose and throat or odor) are
not adequate to prevent overexposure from inhalation. This material can produce asthmatic sensitization
upon either single inhalation exposure to a relatively high concentration or upon repeated inhalation
exposures to lower concentrations. Individuals with lung or breathing problems or prior allergic reactions
to isocyanates must not be exposed to vapor or spray mist. Avoid contact with skin and eyes. Wear
appropriate eye and skin protection. Wash thoroughly after handling. Do not breathe smoke and gases
created by overheating or burning this material. Decomposition products can be highly toxic and irritating.
Store in tightly closed containers to prevent moisture contamination. Do not reseal if contamination is
suspected.
Further Info on Storage Conditions
Employee education and training in the safe use and handling of this product are required under the OSHA
Hazard Communication Standard 29 CFR 1910.1200.
8. Exposure Controls / Personal Protection

Isophorone Diisocyanate(IPDI) (4098-71-9)

Benzoyl Chloride (98-88-4)
Hazard Designation: Group A4 Not classifiable as a human carcinogen.
Industrial Hygiene/Ventilation Measures
Local exhaust should be used to maintain levels below the TLV whenever this diisocyanate is heated,
sprayed, or aerosolized. Standard reference sources regarding industrial ventilation (e.g., ACGIH Industrial
Ventilation Manual) should be consulted for guidance about adequate ventilation. To ensure that published
exposure limits have not been exceeded, monitoring for airborne diisocyanate should become part of the
overall employee exposure characterization program. NIOSH, OSHA, Bayer, and others have developed
sampling and analytical methods. Bayer methods can be made available, upon request.
Respiratory Protection
Airborne IPDI concentrations greater than the appropriate standard/guideline can occur in inadequately
ventilated environments when IPDI is sprayed, aerosolized, or heated. In such cases, respiratory protection
must be worn. The type of respiratory protection selected must comply with the requirements set forth in
OSHA's Respiratory Protection Standard (29 CFR1910.134). The type of respiratory protection available
includes (1) an atmosphere-supplying respirator such as a self-contained breathing apparatus (SCBA) or a
supplied air respirator (SAR) in the positive pressure or continuous flow mode, or (2) an air-purifying
respirator (APR). If an APR is selected, the following conditions must be met:(1) (a) the cartridge must be
equipped with an end-of-service life indicator (ESLI) certified by NIOSH, or (1) (b) a change out schedule,
based on objective information or data that will ensure that the cartridges are changed out before the end of
their service life, must be developed and implemented. The basis for the change out schedule must be
described in the written respirator program, and (2) the airborne IPDI concentration must be no greater than
10 times the appropriate standard/guideline. The recommended APR cartridge is an organic
vapor/particulate filter combination cartridge (OV/P100).
Hand Protection
Gloves should be worn., Nitrile rubber gloves., Butyl rubber gloves., Neoprene gloves
Eye Protection
When directly handling liquid product, eye protection is required. Examples of eye protection include a
chemical safety goggle, or chemical safety goggle in combination with a full face shield when there is a
greater risk of splash.
Skin and body protection
Any area of skin that could potentially come in contact with this diisocyanate, or a formulation containing
this diisocyanate, must be covered by a permeation resistant barrier (e.g., butyl or nitrile rubber gloves,
neoprene apron, chemical suit, etc.). When there is potential for a major splash directly onto the skin, such
as when breaking into lines, a full chemical suit is required. When the application results in airborne vapor
or mist, a full permeation resistant suit, including head covering, faceshield, gloves and overshoes, is
required.
Medical Surveillance
All applicants who are assigned to an isocyanate work area should undergo a pre-placement medical
evaluation. A history of eczema or respiratory allergies such as hay fever, are possible reasons for medical
exclusion from isocyanate areas. Applicants who have a history of adult asthma should be restricted from
work with isocyanates. Applicants with a history of prior isocyanate sensitization should be excluded from
further work with isocyanates. A comprehensive annual medical surveillance program should be instituted
for all employees who are potentially exposed to diisocyanates. Once a worker has been diagnosed as
sensitized to any isocyanate, no further exposure can be permitted. Refer to the Bayer pamphlet (Medical
Surveillance Program for Isocyanate Workers) for additional guidance.
Additional Protective Measures
Emergency showers and eye wash stations should be available. Educate and train employees in the safe use
and handling of this product. Follow all label instructions.
9. Physical and chemical properties
Appearance:
Boiling Point/Range:
Approximately 300 °C (572 °F) @ 1,013 mbar Flash Point:
Lower Explosion Limit:
Upper Explosion Limit:
Vapor Pressure:
Approximately 52 mbar @ 55 °C (131 °F) Specific Gravity:
Solubility in Water:
Insoluble - Reacts slowly with water to liberate CO2 gas Autoignition Temperature:
Viscosity, Dynamic:
Approximately 13,000 mPa.s @ 20 °C (68 °F) Bulk Density:
Approximately 8.679 lb/gal @ 20 °C (68 °F) Pour Point:
Approximately -12 °C (10.4 °F) (DIN ISO 3016) 10. Stability and Reactivity

Hazardous Reactions
Contact with moisture, other materials that react with isocyanates, or temperatures above 350 F (177 C),
may cause polymerization.
Materials to avoid
Water, Amines, Strong bases, Alcohols, copper alloys
Hazardous decomposition products
By Fire and High Heat: Carbon dioxide (CO2), carbon monoxide (CO), oxides of nitrogen (NOx), dense
black smoke, Hydrogen cyanide, Isocyanate, Isocyanic Acid, Other undetermined compounds
11. Toxicological Information

Toxicity Data for Aliphatic Polyisocyanate based on IPDI
Acute Oral Toxicity
LD50: > 5,000 mg/kg (Rat)
Skin Irritation
rabbit, Non-irritating
Eye Irritation
rabbit, Non-irritating
Sensitization
inhalation: non-sensitizer
Toxicity Data for Isophorone Diisocyanate(IPDI)
Acute Oral Toxicity
LD50: 5,490 mg/kg (Rat)
Acute Inhalation Toxicity
LC50: 40 mg/m3, aerosol, 4 hrs (Rat)
LC50: 260 mg/m3, 1 hrs (Rat)
RD50: 0.218 ppm, 3 hrs (mouse)
Acute dermal toxicity
LD50: 4,780 mg/kg (rabbit)
Skin Irritation
rabbit, Draize, Severely irritating
Eye Irritation
rabbit, Draize, Severely irritating
Sensitization
dermal: sensitizer (guinea pig, Maximisation Test (GPMT))
dermal: sensitizer (guinea pig, Buehler Test)
inhalation: sensitizer (Human, Other method)
dermal: sensitizer (Human, Patch Test)
Repeated Dose Toxicity
28 Days, Inhalation: NOAEL: 0.00064 mg/l, (Rat, male, daily)
1 Week, inhalation: NOAEL: 1.04 mg/m3, (Rat, Male/Female, 6 hrs/day 5 days/week)
Mutagenicity
Genetic Toxicity in Vitro:
Ames: negative (Salmonella typhimurium, Metabolic Activation: with/without)
Toxicity to Reproduction/Fertility
inhalation, 6 hrs/day 7 days/week, (Rat, Female) NOAEL (parental): 1 mg/m3 air/day, NOAEL (F2): 1
mg/m3 air/day
Toxicity Data for Benzoyl Chloride
Acute Oral Toxicity
LD50: 1,900 mg/kg (Rat)
LD50: Approximately 2,500 mg/kg (Rat)
Acute Inhalation Toxicity
LC50: 1.87 mg/l, 2 hrs (Rat)
LC50: Approximately 1.45 mg/l, 4 h (Rat)
Acute dermal toxicity
LD50: 790 mg/kg (rabbit)
Skin Irritation
rabbit, Corrosive
Eye Irritation
rabbit, Corrosive
Sensitization
dermal: sensitizer (Guinea pig, Maximisation Test (GPMT))
Repeated Dose Toxicity
dermal: NOAEL: < 2.3 ul/animal, (mouse, female)
Mutagenicity
Genetic Toxicity in Vitro:
Ames: positive (Salmonella typhimurium, Metabolic Activation: with/without)
Genetic Toxicity in Vivo:
Micronucleus Assay: negative (mouse, Male/Female, oral)
Carcinogenicity
mouse, dermal, 42 - 50 Weeks,
negative
12. Ecological Information

Ecological Data for Isophorone Diisocyanate(IPDI)
Biodegradation
aerobic, 62 %, Exposure time: 28 Days
Acute and Prolonged Toxicity to Fish
LC50: 1.8 mg/l (Golden orfe (Leuciscus idus), 48 hrs)
Acute Toxicity to Aquatic Invertebrates
EC50: 27 - 83.7 mg/l (Water flea (Daphnia magna), 24 hrs)
Toxicity to Aquatic Plants
EC50: 118.7 mg/l, End Point: growth (Green algae (Scenedesmus subspicatus), 72 hrs)
Toxicity to Microorganisms
EC10: 554 mg/l, (Pseudomonas putida, 6 hrs)
Ecological Data for Benzoyl Chloride
Biodegradation
aerobic, 95 %, Exposure time: 20 Days
Bioaccumulation
Does not bioaccumulate.
Acute and Prolonged Toxicity to Fish
LC50: 7.5 - 10 mg/l (Zebra fish (Brachydanio rerio), 96 hrs)
LC50: 34.7 mg/l (Fathead minnow (Pimephales promelas), 96 hrs)
LC0: 200 mg/l (Golden orfe (Leuciscus idus), 72 h)
Acute Toxicity to Aquatic Invertebrates
LC50: 180 mg/l ((Palaemonetes pugio), 96 hrs)
Toxicity to Microorganisms
EC50: 12.24 mg/l, (Photobacterium phosphoreum, 30 min)
EC50: > 100 mg/l, (Activated sludge microorganisms, 3 hrs)
Additional Ecotoxicological Remarks
Harmful ecological effects due to the pH shift are expected.
13. Disposal considerations

Waste Disposal Method
Waste disposal should be in accordance with existing federal, state and local environmental control laws.
Incineration is the preferred method.
Empty Container Precautions
Empty containers retain product residue; observe all precautions for product. Do not heat or cut empty
container with electric or gas torch because highly toxic vapors and gases are formed. Do not reuse without
thorough commercial cleaning and reconditioning. If container is to be disposed, ensure all product
residues are removed prior to disposal.
14. Transportation information

Land transport (DOT)
Non-Regulated


Sea transport (IMDG)
Non-Regulated

Air transport (ICAO/IATA)
Non-Regulated

15. Regulatory Information

United States Federal Regulations

OSHA Hazcom Standard Rating:

US. Toxic Substances Control Act:

US. EPA CERCLA Hazardous Substances (40 CFR 302):
Components
Benzoyl Chloride

SARA Section 311/312 Hazard Categories:
Acute Health Hazard, Chronic Health Hazard
US. EPA Emergency Planning and Community Right-To-Know Act (EPCRA) SARA Title III
Section 302 Extremely Hazardous Substance (40 CFR 355, Appendix A):

Components
Isophorone Diisocyanate(IPDI)
US. EPA Emergency Planning and Community Right-To-Know Act (EPCRA) SARA Title III
Section 313 Toxic Chemicals (40 CFR 372.65) - Supplier Notification Required:

Components
Isophorone Diisocyanate(IPDI)
State Right-To-Know Information
The following chemicals are specifically listed by individual states; other product specific health and safety
data in other sections of the MSDS may also be applicable for state requirements. For details on your
regulatory requirements you should contact the appropriate agency in your state.
Massachusetts, New Jersey or Pennsylvania Right to Know Substance Lists:
Weight %
Components

New Jersey Environmental Hazardous Substances List and/or New Jersey RTK Special Hazardous
Substances Lists:

Weight %
Components

MA Right to Know Extraordinarily Hazardous Substance List:
Weight %
Components

California Prop. 65:
To the best of our knowledge, this product does not contain any of the listed chemicals, which the state of California has found to cause cancer, birth defects or other reproductive harm. 16. Other Information

NFPA 704M Rating
Flammability
Reactivity
0=Insignificant 1=Slight 2=Moderate 3=High 4=Extreme
HMIS Rating
Flammability
Physical Hazard
0=Minimal 1=Slight 2=Moderate 3=Serious 4=Severe * = Chronic Health Hazard The method of hazard communication for Bayer MaterialScience LLC is comprised of Product Labels and Material Safety Data Sheets. HMIS and NFPA ratings are provided by Bayer MaterialScience LLC as a customer service. The handling of products containing reactive IPDI polyisocyanate/prepolymer and/or monomeric IPDI requires appropriate protective measures referred to in this MSDS. These products are therefore recommended only for use in industrial or trade (commercial) applications. They are not suitable for use in Do-It-Yourself applications. Contact Person: This information is furnished without warranty, express or implied. This information is believed to be accurate to the best knowledge of Bayer MaterialScience LLC. The information in this MSDS relates only to the specific material designated herein. Bayer MaterialScience LLC assumes no legal responsibility for use of or reliance upon the information in this MSDS. Changes since the last version will be highlighted in the margin. This version replaces all previous versions.

Source: http://www.purmindex.net/purmmsds/DesmodurVPLS2371MSDS.pdf

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