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Chemical name

List of substances banned for use in cosmetic products as from 1 December 2010
The following substances are classified as CMR substances of category 1A, 1B or 2 under Commission Regulation 790/2009, amending Regulation 1272/2008.1 Therefore they are banned for use in cosmetic products as from 1 December 2010 (which is the date of application of their classification), in accordance with Article 15 of the Cosmetics Regulation Please note that some of the substances classified as CMR substances under Commission Regulation (EC) No 790/2009 had already been regulated in Annex II to the Cosmetics
Regulation through previous adaptations to technical progress of the Annexes to the
Cosmetics Directive (which had been taken over by the Cosmetics Regulation at the time of
its adoption in November 2009). They continue therefore to be listed in this Annex and to
be banned for use in cosmetics, and are thus not included in the list below.
In addition, some substances classified as CMR substances under Commission Regulation (EC) No 790/2009 are considered to be covered by existing entries in Annex II to the
Cosmetics Regulation and are not included in the list below.
Chemical name
O-isobutyl-N-ethoxy carbonylthiocarbamate reaction mass of: 4,7-bis(mercaptomethyl)-3,6,9-trithia- 4,8-bis(mercaptomethyl)-3,6,9-trithia-1,11-undecanedithiol; 5,7-bis(mercaptomethyl)-3,6,9-trithia-1,11-undecanedithiol cobalt acetate 1 This list does not contain the substance Musk Ketone (CAS 81-14-1), even though it has been classified as a CMR 2 substance by Commission Regulation 790/2009. Indeed, Musk Ketone is already listed under Annex III, entry 97 of the Cosmetics Regulation and the data as published in the RAR on Musk Ketone, which was the basis for the official CMR2 classification of the material, was also taken into consideration in the second review of the material by the SCCNFP in 2004, which led to the transfer of the material from a preliminary regulation (Annex III, part 2 of the Cosmetics Directive) to a permanent regulation (Annex III, part 1 of the Cosmetics Directive) in the same year. Therefore, it can be considered that this substance has been subject to "evaluation and approval" of the SCCS and that it remains regulated in Annex III to the Cosmetics Regulation, entry 97. Chemical name
methylbenzenesulfonamide)diphenylmethane 6-glycidyloxynapht-1-yl oxymethyloxirane (E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2- 2-butyryl-3-hydroxy-5-thiocyclohexan-3-yl-cyclohex-2- 2-{(EZ)-1-[(2RS)-2-(4-chlorophenoxy)propoxyimino]butyl}-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one tepraloxydim (ISO); (RS)-(EZ)-2-{1-[(2E)-3-chloroallyloxyimino]propyl}-3- hydroxy-5-perhydropyran-4-ylcyclohex-2-en-1-one 1,2-benzenedicarboxylic acid; reaction mass of: diester of 4,4'-methylenebis[2-(2- hydroxy-5-methylbenzyl)-3,6-dimethylphenol] and 6- diazo-5,6-dihydro-5-oxonaphthalene-1-sulfonic acid (1:2); triester of 4,4'-methylenebis[2-(2-hydroxy-5-methylbenzyl)-3,6-dimethylphenol] and 6-diazo-5,6-dihydro-5-oxonaphthalene-1-sulfonic acid (1:3) diammonium 1-hydroxy-2-(4-(4-carboxyphenylazo)- naphthalenesulfonate 3-oxoandrost-4-ene-17-β-carboxylic acid (Z)-2-methoxymino-2-[2-(tritylamino)thiazol-4-yl]acetic 431-520-1 Chemical name
dipersuccinic acid; monomethyl ester of succinic acid; monomethyl ester of persuccinic acid; dimethyl succinate; glutaric acid; monoperglutaric acid; diperglutaric acid; monomethyl ester of glutaric acid; monomethyl ester of perglutaric acid; dimethyl glutarate; adipic acid; monoperadipic acid; diperadipic acid; monomethyl ester of adipic acid; monomethyl ester of peradipic acid; dimethyl adipate; hydrogen peroxide; methanol; water 4-mesyl-2-nitrotoluene 430-550-0 4-phenylazophenylene-1,3-diamine monohydrochloride; 278-290-5 [2] 4-(phenylazo)benzene-1,3-diamine monoacetate; [2] 4-(phenylazo)benzene-1,3-diamine acetate; [3] chrysoidine-p-dodecylbenzenesulfonate; dodecylbenzenesulfonic acid, compound with 4-(phenylazo)benzene-1,3-diamine (1:1); [4] chrysoidine dihydrochloride; 4-(phenylazo)benzene-1,3-diamine dihydrochloride; [5] chrysoidine sulfate; bis[4-(phenylazo)benzene-1,3-diamine] sulfate [6] *chrysoidine C10-14-alkyl derivatives and; benzenesulfonic acid, mono-C10-14-alkyl derivatives, compounds with 4-(phenylazo)-1,3-benzenediamine; [1] chrysoidine compound with dibutylnaphthalene sulfonic acid; dibutylnaphthalenesulfonic acid, compound with 4-(phenylazo)benzene-1,3-diamine (1:1) [2] piperazine; * These substances are prohibited when used as a substance in hair dye products, under entry 1293 of Annex II to
Regulation 1223/2009. However, as from 1 December 2010, they are banned for use in all cosmetic products.
Chemical name
4-methyl-N-phenyl-6-(1-propynyl)-2-pyrimidinamine (6R-trans)-1-((7-ammonio-2-carboxylato-8-oxo-5-thia- 1-azabicyclo-[4.2.0]oct-2-en-3-yl)methyl)pyridinium ethyl (Z)-2-chloro-3-[2-chloro-5-(cyclohex-1-ene-1,2- dicarboximido)phenyl]acrylate N-[6,9-dihydro-9-[[2-hydroxy-1- (hydroxymethyl)ethoxy]methyl]-6-oxo-1H-purin-2- 2,2'-((3,3',5,5'-tetramethyl-(1,1'-biphenyl)-4,4'-diyl)- trifluralin (ISO) (containing < 0.5 ppm NPDA); α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine (containing < 0.5 ppm NPDA); 2,6-dinitro-N,N-dipropyl-4-trifluoromethylaniline (containing < 0.5 ppm NPDA); N,N-dipropyl-2,6-dinitro-4-trifluoromethylaniline (containing < 0.5 ppm NPDA) piperazine; hydroxylamine sulfate (2:1) [2] 4,4'-methylenediphenyl diisocyanate; o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] mancozeb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) manganese ethylenebis(dithiocarbamate) (polymeric) ethyl N-[2,3-dihydro-2,2-dimethylbenzofuran-7- yloxycarbonyl(methyl)aminothio]-N-isopropyl- β-alaninate phoxim (ISO); α-(diethoxyphosphinothioylimino) phenylacetonitrile Chemical name
(hydroxymethylphosphinyl)butyrate furfuryl alcohol reaction mass of: Ca salicylates (branched C10-14 and C18- 415-930-6 Ca phenates (branched C10-14 and C18-30 alkylated); Ca sulfurised phenates (branched C10-14 and C18-30 alkylated) N,N'-diacetylbenzidine 210-338-2 hydroxylamine 4-methylbenzenesulfonate [4] Refractory Ceramic Fibres, Special Purpose Fibres, with - the exception of those specified elsewhere in this Annex; [Man-made vitreous (silicate) fibres with random orientation with alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+ MgO+BaO) content less or equal to 18 % by weight] O-hexyl-N-ethoxycarbonylthiocarbamate 432-750-3 (hydroxymethylcarbamoyl)ethyl)phosphonate; diethyl (2-(hydroxymethylcarbamoyl)ethyl)phosphonate; methyl ethyl (2-(hydroxymethylcarbamoyl)ethyl)phosphonate (4-phenylbutyl)phosphinic acid potassium titanium oxide (K2Ti6O13) 432-240-0 slimes and sludges, copper electrolytic refining, slimes and sludges, copper electrolyte refining, nickel sulfamate nickel bis(tetrafluoroborate) Chemical name
phosphoric acid, calcium nickel salt; [7] trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) 235-688-3 [5] cobalt nickel oxide [3] nickel tin trioxide; nickel stannate nickel triuranium decaoxide Chemical name
nickel barium titanium primrose priderite; ethyl hydrogen sulfate, nickel(II) salt [3] bis(D-gluconato-O1,O2)nickel; [18] nickel 3,5-bis(tert-butyl)-4-hydroxybenzoate (1:2); [19] 258-051-1 [19] (2-ethylhexanoato-O)(isononanoato-O)nickel; [21] (isononanoato-O)(isooctanoato-O)nickel; [22] (isooctanoato-O)(neodecanoato-O)nickel; [23] (2-ethylhexanoato-O)(isodecanoato-O)nickel; [24] (2-ethylhexanoato-O)(neodecanoato-O)nickel; [25] (isodecanoato-O)(isooctanoato-O)nickel; [26] (isodecanoato-O)(isononanoato-O)nickel; [27] (isononanoato-O)(neodecanoato-O)nickel; [28] fatty acids, C6-19-branched, nickel salts; [29] fatty acids, C8-18 and C18-unsaturated, nickel salts; [30] 2,7-naphthalenedisulfonic acid, nickel(II) salt; [31] molybdenum nickel hydroxide oxide phosphate [4] Chemical name
cobalt dimolybdenum nickel octaoxide; [5] 2,3-epoxypropyltrimethylammonium chloride .%; 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoro-1,1- [containing ≥ 0.1 % 4-chloroaniline (EC No 203-401-0)] 4,4'-(1,3-phenylene-bis(1-methylethylidene))bis-phenol 428-970-4 2-methyl-5-tert-butylthiophenol 444-970-7 cyclic 3-(1,2-ethanediylacetale)-estra-5(10),9(11)-diene- 427-230-8 androsta-1,4,9(11)-triene-3,17-dione 433-560-3 heptadecafluorooctane-1-sulfonic acid; [1] potassium heptadecafluorooctane-1-sulfonate; [2] diethanolamine perfluorooctane sulfonate; [3] ammonium heptadecafluorooctanesulfonate; [4] lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5] ethyl 1-(2,4-dichlorophenyl)-5-(trichloromethyl)-1H- 1-bromo-2-methylpropyl propionate 422-900-6 triammonium 4-[4-[7-(4-carboxylatoanilino)-1-hydroxy- 432-270-4 dimethoxyphenylazo]benzoate reaction mass of: triammonium 6-amino-3-((2,5- diethoxy-4-(3-phosphonophenyl)azo)phenyl)azo-4- hydroxy-2-naphthalenesulfonate; diammonium 3-((4-((7-amino-1-hydroxy-3-sulfo-naphthalen-2-yl)azo)-2,5-diethoxyphenyl)azo)benzoate (3-chloro-2-hydroxypropyl) trimethylammonium 3-(piperazin-1-yl)-benzo[d]isothiazole hydrochloride Chemical name
(2-chloroethyl)(3-hydroxypropyl)ammonium chloride 4-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2- chloro-N,N-dimethylformiminium chloride 7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H- [containing ≥ 0.5 % formamide (EC No 200-842-0) ] reaction products of diisopropanolamine with 3-chloro-4-(3-fluorobenzyloxy)aniline 445-590-4 3,8-diamino-1-ethyl-6-phenylphenantridinium bromide (R,S)-2-amino-3,3-dimethylbutane amide tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one; 1-[4-[4-[[(2SR,4RS)-2-(2,4-dichlorophenyl)-2- (imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone metconazole (ISO); (1RS,5RS;1RS,5SR)-5-(4-chlorobenzyl)-2,2-dimethyl-1- (1H-1,2,4-triazol-1-ylmethyl)cyclopentanol potassium 1-methyl-3-morpholinocarbonyl-4-[3-(1- methyl-3-morpholinocarbonyl-5-oxo-2-pyrazolin-4- ylidene)-1-propenyl]pyrazole-5-olate; [containing ≥ 0.5 % N,N-dimethylformamide (EC No 200-679-5)] N,N',N''-tris(2-methyl-2,3-epoxypropyl)-perhydro-2,4,6- trimethylopropane tri(3-aziridinylpropanoate); (E)-2-(methoxyimino)-N-methyl-2-[α-(2,5-xylyloxy)-o- tolyl]acetamide N,N-(dimethylamino)thioacetamide hydrochloride 435-470-1 27366-72-9 reaction mass of: 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'- 434-330-5 diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)]-3-oxo- butanamide; 2-[[3,3'-dichloro-4'-[[1[[(2,4-dimethylphenyl)amino]carbonyl]-2-oxopropyl]azo][1,1'-biphenyl]-4-yl]azo]-N-(2-methylphenyl)-3-oxo-butanamide; 2-[[3,3'-dichloro-4'-[[1[[(2,4-dimethylphenyl)amino]carbonyl]-2-oxopropyl]azo][1,1'-biphenyl]-4-yl]azo]-N-(2-carboxylphenyl)-3-oxo-butanamide 6,6'-bis(diazo-5,5',6,,6'-tetrahydro-5,5'- dioxo)[methylene-bis(5-(6-diazo-5,6-dihyddro-5-oxo-1-naphthylsulfonyloxy)-6-methyl-2-phenylene]di(naphthalene-1-sulfonate) Chemical name


Reprod Dom Anim 39, 136–140 (2004)Ó 2004 Blackwell Verlag, BerlinISSN 0936-6768Ultrasonography and Cystic Hyperplasia–Pyometra Complex in the BitchE Bigliardi1, E Parmigiani1, S Cavirani2, A Luppi3, L Bonati4 and A Corradi3Units of 1Obstetrics and Reproduction, 2Infectious Diseases, 3Pathology, and 4Internal Medicine, Department of Animal Health, Faculty ofVeterinary Medicine, University o

Microsoft word - 07_ra4.doc

1220 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 3 • Issue 4 • January-March 2011 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 3 • Issue 4 • January – March 2011 Research Paper Preparation and Evaluation of Rapidly Disintegrating Glimepiride Tablets Adel M. Aly 1 , Bassam I

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