Assessment of the efficacy of acetaminophen in the treatment of post weaning multisystemic wasting syndrome in field conditions
A FIELD TRIAL TO ASSESS THE SAFETY AND THE EFFICACY AGAINST M. HYOPNEUMONIAE
OF SIMULTANEOUS USE OF PORCILIS PRRS AND PORCILIS M HYO IN PIGLETS
Patrick Pommier1, Alassane Keita1, Eric Pagot1, Jos Smeets2, Tom Nell2, Bertrand Ridremont3
1CTPA, ZOOPOLE développement, BP 7,22440 Ploufragan, France,
2Intervet International BV, PB 31, 5830AA Boxmeer, The Netherlands, 3 Intervet S.A., BP17144, Beaucouzé, France
Introduction and objectives
In this clinical field study, the safety and efficacy
against Mycoplasma hyopneumoniae (M.h.
) in pigs of
On 3.1% of the piglets from the MHyo and
simultaneous administration of Porcilis MHyo and
MHyo+PRRS groups a minor and transient local reaction
Porcilis PRRS was assessed in comparison with a
could be observed one day after vaccination. By day 4 all
positive control group that received only Porcilis MHyo
reactions had disappeared. No systemic reactions or effects
and a negative (unvaccinated) control group.
on the temperature were observed, except for an immediate
reaction in one piglet after the first MHyo injection. The
1. Materials and methods
pig dropped down, showed erythema and polypnoea during
about 3 minutes, then recovered rapidly and uneventfully.
Porcilis MHyo is an inactivated vaccine against M.h.,
containing α-tocopherol as adjuvant. Porcilis PRRS is
No significant differences between the MHyo
a live vaccine against PRRS.
For simultaneous use the
and MHyo+PRRS groups were observed on lung lesion
freeze-dried PRRS was dissolved in the aqueous
scores (Table 2) and mortality. Porcilis MHyo reduced the
MHyo just prior to use. The trial was a partially
rate of pigs with pneumonic lesions at slaughter from 53%
blinded, randomised, controlled field trial and was
to 33% (p<0.001
). The mean lung lesion score was also
conducted on two farms in France, both being
significantly reduced, from 3.79 to 1.74 (p<0.001
serologically positive for PRRS and infected by M.h.,
significant difference in ADG was observed between the
as confirmed by lung lesions at slaughter.
MHyo and MHyo+PRRS groups during any period. Vaccination with MHyo significantly (p<0.05
the ADG during the fattening period (from 759 g/d to 776
g/d). No effects were found for the other periods (Table 3).
Table 2: Results of lung lesion scores by vaccination group
* % of lungs with lesions/ total number of lungs scored
Animals were monitored closely from 3 days before
until 14 days after second vaccination. Local reactions,
Table 3: ADG (g/day) by period and vaccination group
temperature (on 10 selected animals per group and per
farm), feed intake, and general health were used as
parameters for safety. To determine vaccine efficacy,
the lungs of the pigs were examined at slaughter and
scored for specific lesions of M.h.
and Whittlestone, Br Vet J, 1973, 129, 456-462).
Animals were weighed at weaning, at transfer to the
fattening unit and before slaughter. Mortality was
recorded between weaning and slaughter. The animal
3. Discussion and Conclusion
was the statistical unit. First the effect against M.h.
infection of the simultaneous vaccination was evaluated
Neither the rate of pigs with lung lesions nor any of the
by comparing the results of the MHyo+PRRS and
other parameters showed a significant difference
MHyo groups. Then, data of these two groups were
between MHyo and MHyo+PRRS groups. So, it can be
combined and compared with the unvaccinated control
concluded that simultaneous vaccination with Porcilis
group. Proportions were tested using Cochran Mantel
MHyo and Porcilis PRRS is as safe and efficacious as
Haenszel tests. Lung lesion scores, being ordinal data,
vaccination with only Porcilis MHyo. Vaccination with
were rank-transformed and then analysed by ANOVA.
Porcilis MHyo significantly reduced incidence and extent
Weight gain and temperature were analysed by
of lung lesions and improved ADG during fattening.
ANCOVA. Statistics were made using Systat software.
Annals of Oncology 24 (Supplement 2): ii24–ii29, 2013Intermediate hepatocellular carcinoma: currenttreatments and future perspectivesJ.-F. Dufour1,2*, I. Bargellini3, N. De Maria4, P. De Simone4, I. Goulis5 & R. T. Marinho61Hepatology, Department of Clinical Research, University of Berne, Berne; 2University Clinic for Visceral Surgery and Medicine, Inselspital, University of Berne, Berne,S
Der Bildungssoziologe Dr. Christian Imdorf hat im Rahmen des Forschungsprojekts «Lehrlingsselektion in KMU» die Haltung von Ärzten und Zahnärzten zu männ-selbstverständnis der Mediziner zu irritie-lichen Praxisassistenten untersucht. Seine These: Männliches Personal irritiert das ren. Ausschlaggebend ist dabei nicht die Rollenverständnis der Praxisinhaber – viele meinen sogar, ihre