Durante mucho tiempo no había principios uniformes para la Atribución de nombres a los antibióticos https://antibioticos-wiki.es . Más a menudo se les llama por el nombre genérico o especie del producto, con menos frecuencia-de acuerdo con la estructura química. Algunos antibióticos se nombran de acuerdo con el lugar donde se asignó el producto.

Rzecznikpatentowy.org.pl

Europäisches Patentamt
European Patent Office
Office européen des brevets
EP 0 989 848 B1
EUROPEAN PATENT SPECIFICATION
(51) Int Cl.7: A61K 9/28
of the grant of the patent:
29.09.2004 Bulletin 2004/40
PCT/IB1998/000883
(21) Application number: 98921690.8
(22) Date of filing: 08.06.1998
WO 1998/056360 (17.12.1998 Gazette 1998/50)
(54) FILM-COATED TABLET FOR IMPROVED UPPER GASTROINTESTINAL TRACT SAFETY
FILMÜBERZOGENE TABLETTE FÜR VERBESSERTE VERTRÄGLICHKEIT IM OBERENMAGEN-DARMTRAKT COMPRIME A ENROBAGE PELLICULAIRE A INNOCUITE ACCRUE A L’EGARD DU TRACTUSOESO-GASTRO-DUODENAL • BEKKER, Petrus, Jakobus
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL
Westlake Village - CA 91362 (US)
(74) Representative: Clemo, Nicholas Graham et al
(30) Priority: 11.06.1997 US 49306 P
Procter & Gamble
Patent Department

Technical Centres Limited,
05.04.2000 Bulletin 2000/14
Rusham Park,
Whitehall Lane

(73) Proprietor: THE PROCTER & GAMBLE COMPANY
Egham, Surrey TW20 9NW (GB)
Cincinnati, Ohio 45202 (US)
EP-A- 0 377 439
WO-A-94/12200
• DANSEREAU, Richard, John
WO-A-97/09967
DE-A- 19 615 812
Cincinnati, OH 45208 (US)
DE-U- 8 622 513
US-A- 4 302 440
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may givenotice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art.
99(1) European Patent Convention).
EP 0 989 848 B1
Description
The present invention relates to novel oral dosage forms that protect the epithelial and mucosal tissues of the mouth and the buccal cavity, the pharynx, the larynx, and the esophagus from erosion, ulceration, or other likeirritation suffered by direct contact of these tissues with the active ingredient. The tablet is a modified oval shape andis film coated. This invention further relates to a method of treating or preventing diseases characterized by abnormalcalcium and phosphate metabolism using the novel film coated dosage forms described herein.
The oral administration of certain active ingredients sometimes results in patient complaints shortly after dos- ing; said complaints are usually characterized by the patients as heartburn, esophageal burning, pain and/or difficulty upon swallowing, and/or pain existing behind and/or mid-sternum. It is believed that these complaints originate fromesophagitis or esophageal irritation caused by the erosion, ulceration, or other like irritation of the epithelial and mucosaltissues of the upper gastrointestinal tract, generally the mouth through the stomach, most generally the esophagus. Itis hypothesized that said irritation results from the active ingredient coming in direct contact with those epithelial andmucosal tissues, resulting in the topical irritation thereof. If the dosage form adheres in the esophagus, the active ingredient slowly dissolves and creates a high drug concentration on the mucosal surface of the esophagus.
[0003]
Particularly problematic drugs are those which when dissolved have a pH below 2-3, drugs with cytotoxic activity (caustic) and/or the local development of a hyperosmolar solution which causes mucosal desiccation. Theseactives include but are not limited to emperonium bormide, doxycycline, and other tetracyclines/antibiotics, iron prep-arations, quinidine, nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine (AZT) and bisphosphonates.
[0004]
Dosage forms have been developed to delay the release of the active ingredients after passage through the upper gastrointestinal tract and in some cases through the stomach, i.e., enteric coated tablets. But, in certain instancesits is undesirable or unnecessary for a medicant to be in a delayed release dosage form. Accordingly, it became de-sirable to develop novel oral dosage forms which would facilitate rapid esophageal transit, minimize or avoid the release of an active compound in the upper gastrointestinal tract and deliver the active ingredient to the stomach. Said noveloral dosage forms are oval shaped tablets, including modified oval and caplet shaped tablets and are film coated tofacilitate rapid esophageal transit and release the active in the stomach thereby, providing protection to the tissues ofthe mouth, pharynx, and esophagus. Most preferred are novel modified oval shape, film coated oral dosage forms thatcontain a bisphonates such as risedronate or alendronate.
DE 196 15 812, EP 377 439, US 4 302 440; WO 97/09967, WO 94/12200 and DE 86 22 513 describe a variety of oral dosage forms for delivery of various active ingredients.
The present invention is directed to a pharmaceutical formulation in an oral generally oval shaped, including but not limited to oval, modified oval and caplet shaped form. The dosage form is film coated and comprised of a safeand effective amount of an active ingredient and pharmaceutically-acceptable excipients. Said dosage forms facilitaterapid esophageal transit time thereby avoiding the release of active ingredient in the buccal cavity, pharynx, and es-ophagus and protecting the epithelial and mucosal tissues thereof from erosion, ulceration or other like irritation.
Accordingly, the novel dosage forms described herein effect the delivery to the stomach of said human or other mammal of a safe and effective amount of active ingredient, and substantially alleviates esophagitis or esophagealirritation which sometimes accompanies the oral administration of certain active ingredients.
FIG. 1 shows a top plan view of a modified oval tablet;FIG. 2 is a side elevation view thereof; and FIG. 3 is an end view of said modified oval tablet.
EP 0 989 848 B1
DETAILED DESCRIPTION OF THE PRESENT INVENTION The present invention is directed to a novel generally oval shaped, film coated oral dosage form comprising a safe and effective amount of an active ingredient and pharmaceutically-acceptable excipients according to claim 1.
Said dosage forms facilitates rapid esophageal transit thereby avoiding or minimizing the release of the active ingredient
in the mouth, pharynx, and esophagus and protecting the epithelial and mucosal tissues thereof from erosion, ulceration
or other like irritation. Particularly preferred are modified oval shaped, film coated oral dosage forms.
[0010]
Accordingly, the said dosage forms effect the delivery to the stomach of said human or other mammal of a safe and effective amount of the active ingredient, and substantially alleviate esophagitis or esophageal irritation which occasionally accompanies the oral administration of active ingredients.
[0011]
The invention further comprises a method of treating diseases characterized by abnormal calcium and phos- phate metabolism comprising administering to a human or other mammal afflicted with such a disease a novel oralform as described herein.
The active ingredient herein may be any ingredient that yields a therapeutic benefit and is required to be delivered to the stomach of said human or other mammal. The benefits of the present invention are particularly realizedwhen the active ingredient if released prior to entering the stomach may cause patient complaints such as heartburn, esophageal burning, pain and/or difficulty upon swallowing, and/or pain existing behind and/or mid-sternum. Suchactive ingredients are those which when dissolved have a pH below 2-3, drugs with cytotoxic activity (caustic) and/orthe local development of a hyperosmolar solution which causes mucosal desiccation. Preferred actives are selectedfrom the group consisting of emperonium bormide, doxycycline, and other tetracyclines/antibiotics, iron preparations,potassium chloride, quinidine, nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine (AZT) and bisphosphonates. More preferred actives are risedronate, alendronate and pamidronate, most
preferred is risedronate.
[0013]
The disphosphonates of the present invention are structural variations of the geminal grouping: The term "risedronate", as used herein, denotes the disphosphonate compound 3-pyridyl-1-hydroxyethyli- dene-1,1-bisphosphonic acid and has the following structure: The compound risedronate is further described in U.S. Patent 5,583,122, Benedict et al., assigned to the Procter & Gamble Co., issued December 10, 1996, and "An American Conference, Bisphosphonates: Current Status
and future Prospects, The Royal College of Physicians, London, England, May 21-22, 1990, organized by IBC Technical
Services, both references hereby are incorporated by reference.
[0016]
The term "risedronate active ingredient" includes risedronate, risedronate salts, and risedronate esters, or any mixture thereof. Any pharmaceutically-acceptable, non-toxic salt or ester of risedronate may be used as the rise- dronate active ingredient in the novel oral dosage forms of the present invention. The salts of risedronate may be acidaddition salts, in particular the hydrochloride, but any pharmaceutically-acceptable, non-toxic organic or inorganic acidsalt may be used. In addition, salts formed with the phosphonic acid group may be used, including, but not limited toalkali metal salts (K, Na) and alkaline earth metal salts (Ca, Mg) the Ca and Na salts being preferred.
EP 0 989 848 B1
Particularly, other esters of risedronate which are suitable for use as the active ingredient herein are straight chain or branched chain C1-C18 alkyl esters, including, but not limited to, methyl, ethyl, propyl, isopropyl butyl, isobutyl,amyl hexyl, heptyl, octyl, nonyl, decyl, lauryl, myristyl, cetyl, and stearyl; straight chain or branched C2-C18 alkenyl,esters, including but not limited to vinyl, alkyl, undecenyl, and linolenyl; C3-C8 cycloalkyl esters, including, but not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl; aryl ester, including, but not
limited to phenyl, toluyl, xylyl, and naphthyl; alicyclic esters, including, but not limited to, menthyl; and aralkyl esters,
including, but not limited to benzyl, and phenethyl.
[0018]
The term "alendronate" as used herein, denotes the disphosphate compound 4-amino-1-hydroxybutylidene- 1,1-bisphosphonic acid and its pharmaceutically-acceptable salts, i.e. monosodium trihydrate. The compound alendr- onate is further described in U.S. Patents 4,922,007 and 5,019,651 both issued to Merck and both hereby incorporated
by reference.
[0019]
Generally speaking, the proper selection of the active ingredient depends on the selected type of formulation, the disease pattern, especially the site and type of the disease, and the desired release of the active ingredient. Inaddition, the physical and chemical characteristics of the active ingredient must be taken into account when selecting suitable pharmaceutically-acceptable excipients for use in the novel dosage forms containing the active ingredient.
[0020]
The effective oral dose of the active ingredient depends on the extent of the disease. For examples, for adults the amount of risedronate usually amounts to from about 1 mg to about 40 mg daily, preferably from about 1 mg toabout 30 mg daily. When the dose is to be administered continuously, the preferred dose is from 1-15 mg/day, preferablyfrom 1-10 mg/day. When the dose is to be administered cyclically, the dose is preferably from 5-40 mg/day, preferably B. Site of Delivery of the Active Ingredient A human or other mammal suffering from various diseases or disorders can be successfully treated by the delivery of the novel dosage form containing the active ingredient to the stomach of said human or other mammal. Thenovel oral generally oval shaped, film coated dosage forms described herein facilitate rapid transit through the esopha-gus thus effectively delivering the dosage form to the stomach and avoiding or minimizing the undesired release ofrisedronate in the mouth, pharynx and/or the esophagus thereby prohibiting the erosion, ulceration or other like irritationof the epithelial or mucosal layers of these tissues. The term "gastrointestinal tract" as used herein relates to the alimentary canal, i.e., that musculo-membranous tube about thirty feet in length, extending from the mouth to the anus.
The term "upper gastrointestinal tract" as used herein means the buccal cavity, the pharynx, the esophagus, and the
stomach. The term "lower gastrointestinal tract" as used herein means the small intestine, and the large intestine.
[0022]
The term "buccal cavity" means the mouth or oral cavity and is lined with a mucous membrane which is continuous with the integument of the lips and with the mucous lining of the pharynx.
The term "pharynx" relates to the part of the upper gastrointestinal tract which is placed behind the nose, mouth and larynx. It is a mucomembraneous tube about 4 inches in length and posteriorily with the esophagus and is
composed of a mucous coat, a fibrous coat, and a muscular coat.
[0024]
The term "esophagus" as used herein is a muscular canal about nine inches long extending from the pharynx to the stomach. The esophagus has three coats; and internal mucous coat surrounding the lumen, a middle aveolar coat and an external muscular coat.
[0025]
The term "stomach" as used herein means that part of the gastrointestinal tract between the esophagus and The term "film-coated" as used herein relates to a mixture of pharmaceutically-acceptable excipients which is applied to, combined with, mixed with or otherwise added to the active ingredients. The said coating may be appliedto a compressed tablet, beads, granules, or particles of active ingredient that are compressed into tablets. The coatingchosen must be compatible with the particular active ingredient selected.
Accordingly, the said film coating is preferably applied to a compressed tablet which contains particles or granules of active ingredient; however, in the event the particles or granules are themselves film-coated before beingcompressed into a tablet, then the film coating of the compressed tablet itself is optional. Because of their film coating,these novel dosage forms will avoid the undesirable delivery of the active ingredient to the mucosal and epithelialtissues of the upper gastrointestinal tract, especially the mouth, pharynx and esophagus. Said coating also achieves the delivery of the active to the stomach which can be manipulated by one skilled in the art by choosing the excipients
which make up the coating, its type, and/or its thickness.
[0028]
Preferred polymers for film-coating are soluble at pH of from about 1.2 to about 5. Particularly preferred polymers are selected from the group consisting of hydroxypropylmethylcellulose (HPMC) alone and/or in combination EP 0 989 848 B1
with hydroxypropylcellulose (HPC), carboxymethylcellulose, methylcellulose, ethylcellulose, acrylic resins, and poly-vinylpyrrolidone and gelatin or other commercially available film-coating preparations such as Dri-Klear, manufacturedby Crompton & Knowles Corp., Mahwah, NJ or Opadry manufactured by Colorcon, West Point Pennsylvania. Partic-ularly preferred are HPMC, HPC, Dri-Klear and Opadry. The lower viscosity HPMC's grades, E-5 and the E-15 are the preferred grades and the most preferred is the E-5 grade. The preferred concentration of the polymer in the coating
suspension is controlled to yield a viscosity of between 50-250 cps.
[0029]
The amount of coating deposited on the tablet is usually in the range of from about 2% to about 5% weight gain with a preferred weight gain of about 3%. The coating can, and usually will, contain a plasticizer. The preferredplasticizers are polyethylene glycol and polypropylene glycol and the most preferred plasticizer is polyethylene glycol.
The preferred amount of plasticizer is from about 15% to about 40% with respect to the film-forming polymer, with themost preferred level of about 20%. Dyes or pigments may also be added to provide the required opacity and color tothe film-coating. The preferred level of the pigment is from about 10% to about 40% with respect to the film-formingpolymer, with the most preferred level of from about 20% to about 30%. Other additives may be added to minimizefoam or to facilitate spraying of the solution on the tablets.
D. Novel Generally Oval Shaped, Film Coated Oral Dosage Forms for Delivery of the Active Ingredient containingDosage Form to the Stomach As stated hereinabove, the present invention is directed to novel generally oval shaped, film-coated oral dos- age forms of an active ingredient to effect delivery to the stomach of a human or other mammal. The novel generallyoval shaped, film-coated dosage form facilitates rapid transit through the upper gastrointestinal tract and avoids thedelivery of the active ingredient until it reaches the stomach of the individual. Upon reaching the stomach the dosageform dissolves and absorbtion of the active ingredient through the small and/or large intestine can be achieved. Thus.
tissues of the upper gastrointestinal tract, especially the epithelial and mucosal layers of the buccai cavity, the pharynx and esophagus are spared direct contact with the active ingredient and the active ingredient is absorbed at the appro-
priate site. Said oral dosage form, therefore, substantially alleviates the esophagitis or esophageal irritation which
occasionally occurs upon oral administration of pharmaceutical compositions containing certain active ingredients.
[0031]
Accordingly, oral dosage forms suitable for use herein are oval shape and are film coated, preferably modified oval shape. A modified oval dosage form is demonstrated in FIGs 1 -3. The dosage forms are formulated with active ingredients along with suitable pharmaceutical excipients which are well-known to those skilled in the art as describedhereinbelow and are formed into the appropriate shape using apparatuses and/or methods which are well-known tothose skilled in the art. The oval tablets have the following dimensions: length from about 0.58 to 2.16 cm (0.23 toabout 0.85 inches) preferably from about 0.64 to 1.9 cm (0.25 to about 0.75 inches), width from about 0.28 to 1.02 cm(0.11 to about 0.4 inches) preferably from about 0.38 to 0.89 cm (0.15 to about 0.35 inches), and a thickness of from about 0.19 to 0.76 cm (0.075 to about 0.3 inches), preferably from about 0.25 to 0.64 cm (0.10 to about 0.25 inches).
The modified oval tablet as shown in FIGs 1-3 may have the following dimensions: a length of about 1.16 cm (0.455
inches), width of about 0.57 cm (0.225) and a thickness of approximately 0.399 cm (0.157 inches).
[0032]
The term "pharmaceutical composition" means an oral dosage form comprised of a safe and effective amount of an active ingredient and pharmaceutically-acceptable excipients. The pharmaceutical compositions described herein are comprised of from about, 0.1% to about 99%, preferably from about 0.5% to about 95% of an active ingredient,and from about 1% to about 99.9%, preferably from 5.00% to about 99.90% of pharmaceutically-acceptable excipients.
For risedronate the composition comprises, preferably 0.25% to 40%, preferably from about 0.5% to about 30% of arisedronate active ingredient and from about 60% to about 97%, preferably from about 70% to about 99.5% of phar-maceutically-acceptable excipients.
The phrase "safe and effective amount", as used herein means an amount of a compound or composition high enough to significantly positively modify the symptoms and/or condition to be treated, but low enough to avoidserious side effects (at a reasonable benefit/risk ratio), within the scope of sound medical judgment. The safe andeffective amount of active ingredient for use in the method of the invention herein will vary with the particular conditionbeing treated, the age and physical condition of the patient being treated, the severity of the condition, the duration of the treatment, the nature of concurrent therapy, the particular active ingredient being employed, the particular phar-
maceutically-acceptable excipients utilized, and like factors within the knowledge and expertise of the attending phy-
sician.
[0034]
The term "pharmaceutically-acceptable excipients" as used herein includes any physiologically inert, phar- macologically inactive material known to one skilled in the art, which is compatible with the physical and chemical characteristics of the particular active ingredient selected for use. Pharmaceutically-acceptable excipients include, butare not limited to, polymers, resins, plasticizers, fillers, lubricants, binders, disintegrants, solvents, co-solvents, buffersystems, surfactants, preservatives, sweetening agents, flavoring agents, pharmaceutical grade dyes and pigments.
All or part of the pharmaceutically-acceptable excipients contained in the pharmaceutical compositions described here- EP 0 989 848 B1
in is used to make the film coating which is to be utilized in the novel oral dosage forms described herein.
[0035]
The term "oral dosage form" as used herein means any pharmaceutical composition intended to be administer to the stomach of an individual via the mouth of said individual, and for purposes of the present invention, the deliveredform is in the form of a modified oval tablet (preferably film coated) containing granules or particles of active ingredient.
"Film-coated oral dosage form" as used herein relates to an oral dosage form containing a pharmaceutical composition as described herein which utilizes a film coating to effect the release of the active ingredient in the stomach.
The film-coated oral dosage from is a compressed tablet containing granules or particles of the active ingredient, which
may be coated or uncoated.
[0037]
The term "rapid esophageal transit" as used herein means the time it takes for a tablet to pass from the oropharynx to the stomach. Rapid esophageal transit would comprise of transit less than about 90 seconds, preferably
from about 1 to about 60 seconds. Most preferred is less than 20 seconds when taken with 50 ml of water.
[0038]
As stated hereinabove, the ultimate site of topical delivery in the stomach can be satisfactorily controlled by one skilled in the art, by manipulating any one or more of the following: (a) The active ingredient proper;(b) the type of the coating, and the concomitant desirable thickness and permeability (swelling properties) of saidcoating;(c) the time-dependent conditions of the coating itself and/or within the coated tablet, particle, bead, or granule; and(d) the particle size of the granulated active ingredient.
As stated hereinabove, pharmaceutically-acceptable excipients include, but are not limited to polymers, res- ins, plasticizers, fillers, lubricants, binders, disintegrants, solvents, cosolvents, surfactants, preservatives, sweetener
agents, flavoring agents, buffer systems, pharmaceutical-grade dyes and pigments.
[0040]
Flavoring agents among those useful herein include those described in Remington's Pharmaceutical Scienc- es, 18th Edition, Mack Publishing Company, 1990, pp. 1288-1300, incorporated by reference herein. Dyes, or pigmentsamong those useful herein include those described in Handbook of Pharmaceutical Excipients, Second Edition pp.
126-134, 1994 by the American Pharmaceutical Association & the Pharmaceutical Press, incorporated by referenceherein.
Preferred co-solvents include, but are not limited to, ethanol, glycerin, propylene glycol, polyethylene glycol.
Preferred buffer systems include, but are not limited to potassium acetate, boric carbonic, phosphoric, suc- cinic, malic, tartaric, citric, acetic, benzoic, lactic, glyceric, gluconic, glutaric and glutamic. Particularly preferred are
phosphoric, tartaric, citric, and potassium acetate.
[0044]
Preferred surfactants include, but are not limited to, polyoxyethylene sorbitan fatty acid esters, polyoxyethyl- ene monoalkyl ethers, sucrose monoesters and lanolin esters and ethers.
[0045]
Preferred preservatives include, but are not limited to, phenol, alkyl esters of parahydroxybenzoic acid, ben- zoic acid and the salts thereof boric acid and the thereof, sorbic acid and the salts thereof, chorbutanol, benzyl alcohol,thimerosal, phenylmercuric acetate and nitrate, nitromersol, benzalkonium chloride, cetylpyridinium chloride, methylparaben, and propyl paraben. Particularly preferred are the salts of benzoic acid, cetylpyridinium chloride, methyl pa- raben and propyl paraben.
[0046]
Preferred sweeteners include, but are not limited to, sucrose, glucose, saccharin, and aspartame. Particularly preferred are sucrose and saccharin.
[0047]
Preferred binders include, but are not limited to methycellulose, sodium carboxymethycellulose, hydroxypro- pylmethylcellulose, carbomer, providone, acacia, guar gum, xanthan gum and tragacanth. Particularly preferred are methycellulose, carbomer, xanthan gum, guar gum, povidone and sodium carboxymethycellulose.
[0048]
Preferred fillers include, but are not limited to lactose, sucrose, maltodextrin, mannitol, starch, and microc- rystalline cellulose.
[0049]
Preferred plasticizers include, but are not limited to polyethylene glycol, propylene glycol, dibutyl phthalate, and castor oil, acetylated monoglycerides, and triacetin.
Preferred lubricants include, but are not limited to, magnesium stearate, stearic acid, and talc.
Preferred disintegrants include, but are not limited to, orospovidone, sodium carboxymethyl starch, sodium starch glycolate, sodium carboxymethyl cellulose, alginic acid, clays, and ion exchange resins.
[0052]
Preferred polymers, include but are not limited to hydroxypropylmethylcellulose (HPMC) alone and/ or in combination with hydroxypropylcellulose (HPC), carboxymethylcellulose, acrylic resins such as Eudragit® RL30D, manufactured by Rohm Pharma GmbH Weiderstadt, West Germany, methylcellulose, ethylcellulose, and polyvinylpyr-
rolidone or other commercially available film-coating preparations such as Dri-Klear, manufactured by Crompton &
Knowles Corp., Mahwah, NJ or Opadry manufactured by Colorcon, West Point, PA.
[0053]
Utilizing the novel oral dosage forms of the present invention, the active ingredient can be reliably delivered EP 0 989 848 B1
to the stomach thereby avoiding the undesirable exposure of the active in the mucosal and epithelial tissues of themouth, pharynx, and/or esophagus. Said dosage forms render the active ingredient readily available for absorptionfrom the stomach and, there is substantially no contact of the active ingredient upon the epithelial and mucosal tissuesof the mouth, pharynx, or esophagus. Accordingly, the novel modified oval, film-coated oral dosage form of the present invention substantially alleviates the condition of esophagitis or esophageal irritation which occasionally results from
the oral administration of a pharmaceutical composition comprising certain active ingredients.
[0054]
Any film- coating which is soluble in the gastric contents pH 1.2- 5 can be used in the practice of the present invention. The preferred polymer to be used as the film coating must be applied to the compressed tablet, the gelatincapsule and/or beads, particles or granules of active ingredient in a sufficient thickness so that the entire coating dissolves in the stomach. The dissolution or disintegration of the excipient coating generally does not occur until the
entry of the coated dosage form into the stomach.
[0055]
The following non-limiting examples serve to further illustrate the novel oral dosage forms of the present EXAMPLE I
Modified Oval, Film-Coated Risedronate Tablet The film-coating is applied to 110 kg of risedronate core tablets each weighing 240 mg.
Component
kg/batchmg/tablet
Dri-Klear is a mixture of HPMC, HPC, polyethylene glycol, and silicon dioxide manufactured by Crompton and Knowles,Marwah, NJ, Chroma-Tone White is a mixture of HPC and titanium dioxide manufactured by Crompton and Knowles, Marwah, NJ.
[0057]
The coating suspension is prepared as follows: 1. Add the Dri-Klear to hot purified water, 60-80°C, with agitation.
2. Cool the Dri-Klear solution to 40°C or below, with continual mixing until all the Dri-Klear is dissolved.
3. Add the Chroma-Tone White to purified water with mixing. Disperse with the use of a high shear mixer for 10-25minutes.
4. Add the pigment suspension (step 3) to the polymer solution (step 2) and mix. Continue mixing until ready for use.
5. Load the core tablets into a 48 inch side vented coating pan.
6. Preheat the tablets until the exhaust temperature reaches approximately 35°C and begin spraying. Apply the coating suspension using an inlet air temperature of 40-60°C at a rate of 300-400 g/minute.
7. Cool the tablets and discharge.
EXAMPLE II
Caplet shaped, Film-Coated Alendronate Tablet The film-coating is applied to 100 kg of alendronate core tablets each weighing 200 mg.
Component
kg/batch
mg/tablet
Opadry is a commercial film-coating mixture manufactured by Colorcon, West Point, PA. The coating suspension isprepared as follows: EP 0 989 848 B1
1. Add the Opadry to room temperature purified water with agitation.
2. Mix until all the Opadry is dissolved.
3. Add the red iron oxide to purified water with mixing. Disperse with the use of a high shear mixer for 5 minutes.
4. Add the red iron oxide suspension (step 3) to the polymer solution (step 2) and mix. Continue mixing until ready for use.
5. Load the core tablets into a 48 inch side vented coating pan.
6. Preheat the tablets until the exhaust temperature reaches approximately 40°C and begin spraying. Apply thecoating suspension using an inlet air temperature of 40-60°C at a rate of 250-350 g/minute.
7. Cool the tablets and discharge.
EXAMPLE III
The film-coated risedronate tablets are made by preparing granules containing the active, coating the gran- ules, compressing into a tablet and then film-coating the tablets.
A. Preparation of the risedronate sodium granules, 212.5 kg Component
kg/batch
mg/g (Dry basis)
1. Dissolve the polyvinylpyrrolidone in the purified water.
2. Mix the risedronate sodium, lactose and microcrystalline cellulose in a high shear mixer for 3 minutes.
3. Granulate the mixture with the polyvinylpyrrolidone solution with mixing over a 5 minute interval.
4. Dry the wetted mass in a fluid bed dryer at an inlet temperature of 60°C.
5. Mill the dried material using a hammer mill to achieve the desired granule size.
B. Coating of the granules and preparation of risedronate sodium tablets, 130.3 kg Component
kg/batch
mg/tablet
The granulation is coated and compressed into tablets as follows: 1. Dissolve the hydroxypropylmethylcellulose E-15 in purified water at 60°C with continued mixing. Cool to 30°C and mix until dissolved.
2. Add the risedronate sodium granules to a suitable coating column.
3. Spray on the hydroxypropylmethylcellulose E-15 solution at an inlet temperature of 50°C. After coating, drythe coated granules at an inlet temperature of 60°C.
4. Transfer the coated granules to a twin shell blender and add the crospovidone and microcrystalline cellulose and mix for 5 minutes.
5. Add the magnesium stearate and mix for 3 minutes and compress into tablets on a rotary press.
EP 0 989 848 B1
C. Film-coatingFilm-coating is applied to 120 kg of risedronate core tablets each weighing 260.6 mg.
Component
kg/batch
mg/tablet
The coating suspension is prepared as follows; 1. Add the hydroxypropylmethylcellulose E-5 to a portion of the purified water at 80°C, with agitation. Add theremaining purified water at 10°C and mix until dissolved.
2. Add the polyethylene glycol 6000 to purified water with mixing.
3. Add the FD&C Blue #1 lake and the silicon dioxide to the polyethylene glycol solution. Disperse with theuse of a high shear mixer for 10-25 minutes.
4. Add the pigment suspension (step 3) to the polymer solution (step 1) and mix.
5 Load the core tablets into a 48 inch side vented coating pan.
6. Preheat the tablets until the exhaust temperature reaches approximately 40°C and begin spraying. Applythe coating suspension using an inlet air temperature of 40°C at a rate of 250 g/minute.
7. Cool the tablets and discharge.
A novel oral dosage form to be delivered to the stomach, said dosage form comprising a safe and effective amount of an active ingredient selected from the group consisting of tetracycline antibiotics, iron preparations, quinidine,
nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine, bisphospho-
nates or mixtures thereof and pharmaceutically-acceptable excipients, wherein said oral dosage form is charac-
terized by
being generally oval form and film coated to facilitate rapid esophageal transit and avoid irritation in
the mouth, buccal cavity, pharynx, and esophagus, and comprising dimensions of from 0.58 to 2.16 cm (0.23 to
0.85 inches) for length, from 0.28 to 1.02 cm (0.11 to 0.4 inches) for width and from 0.19 to 0.76 cm (0.075 to 0.3inches) for thickness.
A dosage form according to Claim 1 wherein the film coating is soluble at a pH from 1.2 to 5.
A dosage form according to Claims 1 or 2 wherein said film coating is selected from the group consisting of hy-droxypropylmethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, methylcellulose, ethylcellulose,acrylic resins, polyvinylpyrrolidone or gelatin or mixtures thereof.
A dosage form according to any one of the preceding claims wherein said dosage form is a modified oval or caplet A dosage form according to any one of the preceding claims wherein said active ingredient is selected from thegroup consisting of emperonium bromide, doxycycline, iron preparations, potassium chloride, quinidine, nonster-oidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine, risedronate, alendr- onate or pamidronate, or mixtures thereof.
A dosage form according to anyone of the preceding claims wherein said active ingredient is selected from thegroup consisting of risedronate, alendronate or pamidronate.
A dosage form according to anyone of the preceding claims wherein said dosage form comprises form 0.25% to40% of the composition of risedronate.
EP 0 989 848 B1
A novel oral dosage form according to anyone of the preceding claims wherein said dosage form is a compressedtablet comprising particles of the active ingredient and pharmaceutically-acceptable excipients.
A novel oral dosage form according to anyone of the preceding claims wherein said particles of active ingredients Patentansprüche
Neue orale Dosisform, welche dem Magen zuzuführen ist, wobei die Dosisform eine sichere und wirksame Menge
eines Wirkstoffs, gewählt aus der Gruppe, bestehend aus Tetracyclinantibiotika, Eisenpräparaten, Chinidin,
nichtsteroidalen entzündungshemmenden Arzneimitteln, Alprenolol, Ascorbinsäure, Captopril, Theophyllin, Zido-
voudin, Bisphosphonaten oder Mischungen hiervon, und pharmazeutisch annehmbare Exzipienten umfasst, wobei
die orale Dosisform dadurch gekennzeichnet ist, dass sie im allgemeinen eine Ovalform aufweist und filmbe-
schichtet ist, um einen raschen esophagealen Transit zu erleichtern und eine Irritation im Mund, der Mundhöhle,des Rachens und der Speiseröhre zu verhindern, und umfassend Dimensionen von 0,58 bis 2,16 cm (0,23 bis0,85 inches) in der Länge, 0,28 bis 1.02 cm (0.11 bis 0,4 inches) in der Breite und 0,19 bis 0,76 cm (0,075 bis 0,3inches) in der Dicke.
Dosisform nach Anspruch 1, wobei die Filmbeschichtung bei einem pH von 1,2 bis 5 löslich ist.
Dosisform nach Anspruch 1 oder 2, wobei die Filmbeschichtung gewählt ist aus der Gruppe, bestehend aus Hy-droxypropylmethylcellulose, Hydroxypropylcellulose, Carboxymethylcellulose, Methylcellulose, Ethylcellulose,Acrylharzen, Polyvinylpyrrolidon oder Gelatine oder Mischungen hiervon.
Dosisform nach mindestens einem der vorangehenden Ansprüche, wobei die Dosisform eine modifizierte Oval-oder Capletform aufweist (Figuren 1-3).
Dosisform nach mindestens einem der vorangehenden Ansprüche, wobei der Wirkstoff aus der Gruppe gewählt ist, bestehend aus Emperoniumbromid, Doxycyclin, Eisenpräparaten, Kaiumchlorid, Chinidin, nichtsteroidalen ent-zündungshemmenden Arzneimitteln, Alprenolol, Ascorbinsäure, Captopril, Theophyllin, Zidovoudin, Risedronat,Alendronat oder Pamidronat oder Mischungen hiervon.
Dosisform nach mindestens einem der vorangehenden Ansprüche, wobei der Wirkstoff aus der Gruppe gewählt ist, bestehend aus Risedronat, Alendronat oder Pamidronat.
Dosisform nach mindestens einem der vorangehenden Ansprüche, wobei die Dosisform 0,25% bis 40% der Zu-sammensetzung an Risedronat umfasst.
Neue orale Dosisform nach mindestens einem der vorangehenden Ansprüche, wobei die Dosisform eine kompri-mierte Tablette ist, umfassend Teilchen des Wirkstoffs und pharmazeutisch annehmbare Exzipienten.
Neue orale Dosisform nach mindestens einem der vorangehenden Ansprüche, wobei die Teilchen des Wirkstoffsselbst filmbeschichtet sind.
Revendications
Nouvelle forme de dosage orale à délivrer à l'estomac, ladite forme de dosage comprenant une quantité sûre et efficace d'un ingrédient efficace choisi dans le groupe constitué des antibiotiques de type tétracycline, des prépa-
rations à base de fer, de la quinidine, des médicaments anti-inflammatoires non stéroïdiens, de l'alprénolol, de
l'acide ascorbique, du captopril, de la théophylline, de la zidovoudine, des bisphosphonates ou de leurs mélanges
et des excipients pharmaceutiquement acceptables, ladite forme de dosage orale étant caractérisée en ce qu'elle
a une forme généralement ovale et est enrobée d'un film pour faciliter un transit oesophagien rapide et éviter
l'irritation de la bouche, de la cavité buccale, du pharynx et de l'oesophage; et comprenant des dimensions de0,58 à 2,16 cm (0,23 à 0,85 pouce) de long, 0,28 à 1,02 cm (0,11 à 0,4 pouce) de large et 0,19 à 0,76 cm (0,075à 0,3 pouce) d'épaisseur.
EP 0 989 848 B1
Forme de dosage selon la revendication 1, dans laquelle l'enrobage de film est soluble à pH de 1,2 à 5.
Forme de dosage selon la revendication 1 ou 2, dans laquelle ledit enrobage de film est choisi dans le groupeconstitué de l'hydroxypropylméthylcellulose, de l'hydroxypropylcellulose, de la carboxyméthylcellulose, de la mé- thylcellulose, de l'éthylcellulose, des résines acryliques, de la polyvinylpyrrolidone ou de la gélatine ou de leursmélanges.
Forme de dosage selon l'une quelconque des revendications précédentes, dans laquelle ladite forme de dosageest une forme ovale modifiée ou la forme d'un comprimé bombé (Fig. 1 à 3).
Forme de dosage selon l'une quelconque des revendications précédentes, dans laquelle ledit ingrédient actif estchoisi dans le groupe constitué du bromure d'empéronium, de la doxycycline, des préparations à base de fer, duchlorure de potassium, de la quinidine, des médicaments anti-inflammatoires non stéroïdiens, de l'alprénolol, del'acide ascorbique, du captopril, de la théophylline, de la zidovoudine, du risédronate, de l'alendronate ou du pa- Forme de dosage selon l'une quelconque des revendications précédentes, dans laquelle ledit ingrédient actif estchoisi dans le groupe constitué du risédronate, de l'alendronate ou du pamidronate.
Forme de dosage selon l'une quelconque des revendications précédentes, dans laquelle ladite forme de dosagecomprend 0,25% à 40% de risédronate dans sa composition.
Nouvelle forme de dosage orale selon l'une quelconque des revendications précédentes, dans laquelle laditeforme de dosage est un comprimé comprenant des particules de l'ingrédient actif et des excipients pharmaceuti- Nouvelle forme de dosage orale selon l'une quelconque des revendications précédentes dans laquelle lesditesparticules d'ingrédients actifs sont elles-mêmes enrobées d'un film.
EP 0 989 848 B1
EP 0 989 848 B1
EP 0 989 848 B1

Source: http://www.rzecznikpatentowy.org.pl/nie_dla_pat_jed/EP0989848B1.pdf

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Telephone (831) 728- 6250 ♦ Facsimile (831) 728-6276 Welcome back to Amesti Elementary School for the 2010/2011 school year! We hope that our returning students had a restful vacation, and that they are excited to come back to school. To our new families, please know that we are looking forward to getting to know you, and we are delighted to have you here! You are a

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Psychopharmacology (2004) 173:153–159DOI 10.1007/s00213-003-1711-8O R I G I N A L I N V E S T I G A T I O NJessica Werth Cook · Bonnie Spring ·Dennis E. McChargue · Belinda Borrelli ·Brian Hitsman · Raymond Niaura · Nancy J. Keuthen ·Jean KristellerInfluence of fluoxetine on positive and negative affectin a clinic-based smoking cessation trialReceived: 7 July 2003 / Accepted: 30 Octob

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