Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Microsoft word - information for oaxaca.docx

When: Proposed Saturday August 2 – 11, a Monday. Proposed Schedule: August 2-3 arrive, get oriented; historic sites in Oaxaca. August 4-5 Centro de Esperanza Infantil, for more in depth information: http://www.oaxacastreetchildrengrassroots.org/ August 6 tour of historic, cultural, and craft sites in surrounding area. August 7 return to Centro de Esperanza Infantil August 8-9 project in pueblo in surrounding town
Each day we will have breakfast at the hotel; eat out for dinner (many, many restaurants in Oaxaca), lunch site
tbd based on the day.
Transportation: taxi/collectivos between airport and town; during our stay provided by an area tour guide, Eric
Ramirez, of Zapotec heritage, born and raised in the area, educated in California.
Weather: the hottest months are in April/May. In August highs are around 80, lows around 60.
Time: Our Central Standard Time, but Oaxaca does not observe Daylight Savings Time.
Our Projects: we will start meeting as a group in January, once a month. Part of our discussions will include
making choices about projects to take on at the two different sites. At the school we can come up with one big
project, or we can offer presence and assistance each day with ongoing work there. When we start meeting we
will have a description of sample projects done by other visiting groups such as ours, and from there we can
adapt or generate our own project. For work in the area pueblo we have a couple of choices from Eric. While it
might seem easier to have all of these decisions already made so we just need to be told what to do, this
decision making will help us engage in a deeper manner.
Preparing:
1. International Passport required. On the plane you will receive a visa form to fill out as well; you will need to retain that form to exit the country. 2. Vaccinations and medications: when traveling to developing countries you should have up to date tetanus, typhoid, cholera, and Hepatitis B (a series of three shots) vaccinations. No need for malaria medication. Pharmacies/drugstores are common in Oaxaca, but bringing pain reliever, Immodium, Pepto Bismal, and dramamine are all advisable. Recommended that each person have a script filled for Cipro, the ‘traveler’s antibiotic.’ Hand sanitizer. 3. You will be doing a lot of walking, so having comfortable, broken in shoes is a must. Expenses and Money Needed: Cost will be about $2,000/person. Our Diocese has matching funds available, so per person money needed to be raised will be $1,000. We have access to a smaller grant, and some outreach funds. Our hope is to have frequent flyer hours donated to help with air fare costs, which will be the highest cost for the trip. Food is relatively inexpensive; an ample meal for dinner can be around $10, although some nights you/we might want to eat a bit more upscale. During our preparation time we will find out about the various crafts people in the area which will determine how much discretionary funds you might want available to buy souvenirs and gifts. For at least this first trip we hope that money is not an obstacle for participation. Our intention is to forge connections with people there so that we will be making return trips. Funding for future trips will have to be determined then.

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