Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

The impact of program funded nrt on quit rates: arizona’s cessation service experience

The Impact of Program Funded NRT on
Quit Rates: Arizona’s Cessation Service
Experience
Best of the West ConferenceSeptember, 2007 EVALUATION, RESEARCH AND DEVELOPMENT UNIT Funded by the Arizona Department of Health Services Tobacco Cessation Program Evaluation: The
Effect of Nicotine Replacement Therapy (NRT+)
z Opportunity to address effectiveness in “real z Versus “efficacy” in clinical trials EVALUATION, RESEARCH AND DEVELOPMENT UNIT Background: Arizona Department of Health Services
Tobacco Education and Prevention Program (ADHS TEPP)
z Eligibility criteria: at least 18 years of age, enrolled in cessation service, and no contraindications EVALUATION, RESEARCH AND DEVELOPMENT UNIT Purpose of this Study
z Impact of NRT+ use on intensive cessation EVALUATION, RESEARCH AND DEVELOPMENT UNIT z Client intake information- cross-sectional individual data, including demographics and tobacco use z NRT+ distribution system - longitudinal individual z Uncertain about the use of redeemed NRT+ EVALUATION, RESEARCH AND DEVELOPMENT UNIT Methods: Statistics
z Descriptive statistics for utilization of ADHS z Quit rates: clients with vs. without NRT+ EVALUATION, RESEARCH AND DEVELOPMENT UNIT Results: Percent of Clients Who Redeemed Vouchers
80
70
60
50
EVALUATION, RESEARCH AND DEVELOPMENT UNIT Results: NRT Redemption and Demographics
Demographics
% NRT+ redemption
EVALUATION, RESEARCH AND DEVELOPMENT UNIT Results: Redemption of NRT Vouchers
EVALUATION, RESEARCH AND DEVELOPMENT UNIT Results: NRT+ by ASHLine and LP
EVALUATION, RESEARCH AND DEVELOPMENT UNIT Results: Quit rate and NRT+
EVALUATION, RESEARCH AND DEVELOPMENT UNIT Results: Quit Rate by NRT+ Type:
30-day quit rate at 6 month without NRT+
30-day quit rate at 6 month with patch only
30-day quit rate at 6 month with other NRT+
EVALUATION, RESEARCH AND DEVELOPMENT UNIT Conclusions
z About 40% of cessation clients had NRT+ transaction z Patches were the most popular type of NRT+ redeemed, and quit rates for those with patch transaction were similar with other type of NRT+ z NRT+ redemption was associated with quit rates z Further study should examine the relationship between EVALUATION, RESEARCH AND DEVELOPMENT UNIT Methodology Challenges
Difference in program protocols among counties Analysis strategies: look into individual characteristics and longitudinal data carefully EVALUATION, RESEARCH AND DEVELOPMENT UNIT

Source: http://www.smvoelker.com/images/NRTandQuitRates.pdf