Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Sweathelp.org

Common Drugs/Medications Known to Cause Diaphoresis Certain prescription and non-prescription medications can cause diaphoresis (excess perspirationor sweating) as a side effect. A list of common potentially sweat-inducing medications is provided below. Medications are listed by broad therapeutic class. This list is provided as a resource and a service. It is not exhaustive and is in no way meant to replace consultation with a medicalprofessional. Although sweating is a known side effect of the medications listed below, in most cases only a small percentage of people using the medicines experience undue sweating (insome cases less than 1%). Medications noted with an “*” are the most likely to cause sweating and the frequency of sweating as a side effect from these medications may be as high as 50%. Genericnames are listed first. U.S brand names are given in parentheses, if applicable.
Celecoxib (Celebrex®)Dronabinol (Marinol®)\ Fentanyl (Actiq®; Duragesic®; Sublimaze®) Hydrocodone and Acetaminophen (Anexsia®; Bancap HC®; Ceta-Plus®; Co-Gesic®; hycet™; Lorcet®10/650; Lorcet® Plus; Lorcet®-HD [DSC]; Lortab®; Margesic® H; Maxidone™; Norco®; Stagesic®; Vicodin® ES; Vicodin® HP; Vicodin®; Zydone®)Ketorolac (Acular LS™; Acular® PF; Acular®; Toradol®) Methadone (Dolophine®; Methadone Diskets®; Methadone Intensol™; Methadose®)Morphine Sulfate (Astramorph/PF™; Avinza®; DepoDur™; Duramorph®; Infumorph®; Kadian®; MS Contin®; Oramorph SR®; RMS®; Roxanol 100™; Roxanol™-T [DSC]; Roxanol™) Nabumetone (Relafen®)Nalbuphine (Nubain®) Naproxen (Aleve® [OTC]; Anaprox® DS; Anaprox®; EC-Naprosyn®; Midol® Extended Relief;Naprelan®; Naprosyn®; Pamprin® Maximum Strength All Day Relief [OTC]) Oxycodone (OxyContin®; Oxydose™; OxyFast®; OxyIR®; Roxicodone™ Intensol™; RoxicodoneOxycodone and Ibuprofen (Combunox™) Antimicrobials (antibiotics and antivirals)Acyclovir (Zovirax®) Bacitracin (AK-Tracin® [DSC]; Baciguent® [OTC]; BaciiM®) Ceftriaxone (Rocephin®)Ciprofloxacin (Apo-Ciproflox®; Ciloxan®; Cipro® XL; Cipro®; CO Ciprofloxacin; Gen-Ciprofloxacin; Novo-Ciprofloxacin; PMS-Ciprofloxacin; ratio-Ciprofloxacin; Rhoxal-ciprofloxacin)Efavirenz (Sustiva®) Foscarnet (Foscavir®)Gatifloxacin (Tequin®; Zymar™) Mefloquine (Lariam®)Moxifloxacin (Avelox® I.V.; Avelox®; Vigamox™) Nelfinavir (Viracept®)Piperacillin and Tazobactam Sodium (Zosyn®) Praziquantel (Biltricide®)Ribavirin (Copegus®; Rebetol®; Ribasphere™; Virazole®) Cardiovascular (heart and blood pressure)Amlodipine (Norvasc®) Benazepril (Lotensin®)Bumetanide (Bumex®) Digoxin (Digitek®; Lanoxicaps®; Lanoxin®)Dipyridamole (Persantine®) Doxazosin (Cardura®)Enalapril (Vasotec®) HydrALAZINE (NA)Lisinopril (Prinivil®; Zestril®) Metoprolol and Hydrochlorothiazide (Lopressor HCT®)NIFEdipine (Adalat® CC; Afeditab™ CR; Nifediac™ CC; Nifedical™ XL; Procardia XL®; Procardia®) Propafenone (Rythmol® SR; Rythmol®)Ramipril (Altace®) Sotalol (Betapace AF®; Betapace®; Sorine®)Verapamil (Calan® SR; Calan®; Covera-HS®; Isoptin® SR; Verelan® PM; Verelan®) Chemotherapeutic (oncology/cancer)Anastrozole (Arimidex®) Leuprolide (Eligard®; Lupron Depot-Ped®; Lupron Depot®; Lupron®; Viadur®)Tamoxifen (Nolvadex® [DSC]; Soltamox™) Betamethasone (Beta-Val®; Celestone® Soluspan®; Celestone®; Diprolene® AF; Diprolene®; Luxiq®; Maxivate®)Isotretinoin (Accutane®; Amnesteem™; Claravis™; Sotret®) Lidocaine and Epinephrine (LidoSite™; Xylocaine® MPF With Epinephrine; Xylocaine® With Epinephrine)Mepivacaine (Carbocaine®; Polocaine® Dental; Polocaine® MPF; Polocaine®) Selenium Sulfide (Exsel® [DSC]; Head & Shoulders® Intensive Treatment [OTC]; Selsun Blue® 2-in-1Treatment [OTC]; Selsun Blue® Balanced Treatment [OTC]; Selsun Blue® Medicated Treatment [OTC]; Selsun Blue® Moisturizing Treatment [OTC]; Selsun®) Calcitonin (Fortical®; Miacalcin®)Epinephrine (Adrenalin®; EpiPen® Jr; EpiPen®; Primatene® Mist [OTC]; Raphon [OTC]; S2® [OTC]; Twinject™)GlipiZIDE (Glucotrol® XL; Glucotrol®) Insulin Regular (Humulin® R (Concentrated) U-500; Humulin® R; Novolin® R)Levothyroxine (Levothroid®; Levoxyl®; Synthroid®; Unithroid®) MedroxyPROGESTERone (Depo-Provera® Contraceptive; Depo-Provera®; depo-subQ provera 104™; Provera®)PrednisoLONE (AK-Pred®; Bubbli-Pred™ [DSC]; Econopred® Plus; Orapred®; Pediapred®; Pred Forte®; Pred Mild®; Prelone®)Raloxifene (Evista®) Rho(D) Immune Globulin (BayRho-D® Full-Dose; BayRho-D® Mini-Dose; MICRhoGAM®; RhoGAM®;Rhophylac®; WinRho® SDF) Somatropin (Genotropin Miniquick®; Genotropin®; Humatrope®; Norditropin® NordiFlex®; Norditropin®; Nutropin AQ®; Nutropin®; Saizen®; Serostim®; Tev-Tropin™; Zorbtive™)Testosterone (Androderm®; AndroGel®; Delatestryl®; Depo®-Testosterone; First® Testosterone MC; First® Testosterone; Striant®; Testim®; Testopel®)Thyroid (Armour® Thyroid; Nature-Throid® NT; Westhroid®) Tositumomab and Iodine I 131 Tositumomab (131 I Anti-B1 Antibody; 131 I-Anti-B1 MonoclonalAntibody; Anti-CD20-Murine Monoclonal Antibody I-131; B1 Antibody; B1; Iodine I 131 Tositumomab and Tositumomab; Tositumomab I-131) GastrointestinalDiphenoxylate and Atropine (Lomotil®; Lonox®) Dolasetron (Anzemet®)Mesalamine (Asacol®; Canasa™; Pentasa®; Rowasa®) Omeprazole (Prilosec OTC™ [OTC]; Prilosec®) Flunisolide (AeroBid®-M; AeroBid®; Nasarel®)Loratadine (Apo-Loratadine®; Claritin® Kids; Claritin®) Pseudoephedrine (Biofed [OTC]; Contact® Cold [OTC]; Dimetapp® 12-Hour Non-Drowsy Extentabs® [OTC]; Dimetapp® Decongestant Infant [OTC]; ElixSure™ Congestion [OTC]; Genaphed® [OTC];Kidkare Decongestant [OTC]; Kodet SE [OTC]; Oranyl [OTC]; PediaCare® Decongestant Infants [OTC]; Silfedrine Children's [OTC]; Simply Stuffy™ [OTC]; Sudafed® 12 Hour [OTC]; Sudafed® 24 Hour [OTC]; Sudafed® Children's [OTC]; Sudafed® [OTC]; Sudo-Tab® [OTC]; Sudodrin [OTC]; SudoGest [OTC]Triamcinolone (Aristocort® A; Aristocort®; Aristospan®; Azmacort®; Kenalog-10®; Kenalog-40®; Kenalog®; Nasacort® AQ; Tri-Nasal®; Triderm®)Triprolidine and Pseudoephedrine (Actifed® Cold and Allergy [OTC]; Allerfrim® [OTC]; Aphedrid™ [OTC]; Aprodine® [OTC]; Genac® [OTC]; Silafed® [OTC]; Sudafed® Sinus Nighttime [OTC]; Tri-Sudo®[OTC]) Oxymetazoline (4-Way® 12 Hour [OTC]; Afrin® Extra Moisturizing [OTC]; Afrin® Original [OTC]; Afrin® Severe Congestion [OTC]; Afrin® Sinus [OTC]; Duramist® Plus [OTC]; Duration® [OTC]; Genasal [OTC];Neo-Synephrine® 12 Hour Extra Moisturizing [OTC]; Neo-Synephrine® 12 Hour [OTC]; NRS® [OTC]; N_strilla® [OTC]; Vicks Sinex® 12 Hour Ultrafine Mist [OTC]; Vicks Sinex® 12 Hour [OTC]; Visine® L.R.
[OTC]) *Zinc Supplements (Cold-Eeze® [OTC; Galzin™; Orazinc® [OTC]; Zincate®) Hematologic/Immunologic/ImmunosupressantCycloSPORINE (Gengraf®; Neoral®; Restasis™; Sandimmune®) Ferric Gluconate (Ferrlecit®)Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine (Twinrix®) Hepatitis B Vaccine (Engerix-B®; Recombivax HB®)Immune Globulin (Intravenous) (Carimune™ NF; Gammagard® Liquid; Gammagard® S/D; Gammar®- P I.V.; Gamunex®; Iveegam EN; Octagam®; Panglobulin® NF; Polygam® S/D) Infliximab (Remicade®)Mycophenolate (CellCept®; Myfortic®) Buprenorphine (Buprenex®; Subutex®)BusPIRone (BuSpar®) Carbamazepine (Carbatrol®; Epitol®; Equetro™; Tegretol®-XR; Tegretol®)Citalopram (Celexa®) Clozapine (Clozaril®; FazaClo®)*Desipramine (Norpramin®) Dextroamphetamine and Amphetamine (Adderall XR®; Adderall®) Dihydroergotamine (D.H.E. 45®; Migranal®)Donepezil (Aricept® ODT; Aricept®) Duloxetine (Cymbalta®)Escitalopram (Lexapro®) Eszopiclone (Lunesta™)Fluoxetine (Prozac® Weekly™; Prozac®; Sarafem®) Haloperidol (Haldol® Decanoate; Haldol®)Levodopa and Carbidopa (Parcopa™; Sinemet® CR; Sinemet®) Nicotine (Commit™ [OTC]; NicoDerm® CQ® [OTC]; Nicorette® [OTC]; Nicotrol® Inhaler; Nicotrol® NS; Nicotrol® Patch [OTC])*Nortriptyline (Pamelor®) Olanzapine (Zyprexa® Zydis®; Zyprexa®)Paroxetine (Paxil CR®; Paxil®; Pexeva®) Quetiapine (Seroquel®)Rizatriptan (Maxalt-MLT®; Maxalt®) Sumatriptan (Imitrex®)Temazepam (Restoril®) Topiramate (Topamax®)Venlafaxine (Effexor® XR; Effexor®) Ziprasidone (Geodon®)Zolpidem (Ambien CR™; Ambien®) Ophthalmologic (eye)Echothiophate Iodide (Phospholine Iodide®) Naphazoline and Antazoline (Vasocon®-A [OTC] [DSC])Proparacaine (Alcaine®; Ophthetic®) Fluticasone and Salmeterol (Advair Diskus®) Ipratropium and Albuterol (Combivent®; DuoNeb™)Levalbuterol (Xopenex HFA™; Xopenex®) Reference: Lexi-Drugs Database, the official drug reference of the American Pharmacists Association, the National Professional Society of Pharmacists.

Source: http://www.sweathelp.org/pdf/Diaphoretic_Class.pdf