Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.

Co carlow

Co Carlow

Family Resource Centre
Bagnelstown Family Resource Centre
Forward Steps Family Resource Centre

Co Cavan

Family Resource Centre
FOCUS Family Resource Centre
Teach Oscail Resource Project Ltd

Co Clare

Family Resource Centre
Killaloe/Ballina Family Resource Centre
North West Clare Family Resource Centre
Shannon Family Resource Centre
West Clare Family Resource Centre

Co Cork

Family Resource Centre
Adrigole Family Resource Centre
Family Support & Community Wellbeing Project
Cobh Family Resource Centre
Dunmanway Family Resource Centre
Family Support & Community Wellbeing Project
F.A.C.T. Ballincollig FRC
Le Cheile Family Resource Centre
Midleton Community Forum Ltd
Co Donegal

Family Resource Centre
Cara House Family Resource Centre
Donegal Family Resource Centre
Downstrands Family Resource Centre
Dunfanaghy Family Resource Centre
Mevagh Family Resource Centre
Moville & District Family Resource Centre
The Forge Family Resource Centre
Raphoe Family Resource Centre
St. Johnston & Carrigans Family Resource Centre

Dublin

Family Resource Centre
Hill Street Family Resource Centre
St. Andrew's Family Resource Centre
Artane/Coolock Resource and Development Centre
School Street/Thomas Court Bawn FRC
Fatima Group United
Drop in Well Family Resource Centre
St. Matthews Family Resource Centre
Ballyfermot Family Resource Centre
Cherry Orchard Family Resource Centre
Baldoyle Family Resource Centre
Rosemount Comm. Dev. Group
Mountview Resource Centre Ltd
Ballyboden Family Resource Centre
Balally Family Resource Centre
Hillview Community Resource Centre Ltd
Ballyogan Family Resource Centre
Quarryvale Family Resource Centre
Killinarden Family Resource Centre
St. Kevin's Family Resource Centre

Co Galway

Family Resource Centre
Aonad Family Resource Centre
ARD Family Resource Centre
Clann Family Resource Centre
Gort Family Resource Centre
Loughrea Family Resource Centre
Solas Family Resource Centre

Co Kerry

Family Resource Centre
Ballyspillane Community & Family Resource Centre
BUDS Family Resource Centre
Droichead Na Daoine Ltd. (Sneem)
Duagh Family Resource Centre
Kerryhead/Ballyheigue Family Resource Centre
Killorglin Family Resource Centre
Listowel Family Resource Centre
Castlemaine Family Resource Centre
Shanakill Family Resource Centre
Shannow Family Resource Centre
South West Kerry Family Resource Centre
St. Brigid's Community Centre

Co Kildare

Family Resource Centre
Curragh Pride Family Resource Centre
Newbridge Family Resource Centre

Co Kilkenny

Family Resource Centre
Droichead Family Resource Centre
Newpark Close Family Resource Centre
St. Canices Community Action
The Mill Family Resource Centre

Co Laois

Family Resource Centre
Portlaoise Family Resource Centre

Co Leitrim

Family Resource Centre
Breffni Family Resource Centre
Mohill Family Resource Centre
Co Limerick

Family Resource Centre
Croom Family Resource Centre
Hospital Family Resource Centre
Southill Family Resource Centre
Northside Family Resource Centre

Co Longford

Family Resource Centre
Bridgeways Family Resource Centre
Lus Na Greine Family Resource Centre
Co Louth

Family Resource Centre
Connect Family Resource Centre

Co Mayo

Family Resource Centre
Ballina Family Resource Centre
Cairdeas Family Resource Centre
Le Cheile Family Resource Centre
Claremorris Family Resource Centre
Neart hAmhnais Teoranta Family Resource Centre
TACU Family Resource Centre
Westport Family Resource Centre

Co Meath

Family Resource Centre
The Peoples Resource Centre
Trim Family Resource Centre

Co Monaghan

Family Resource Centre
Clones Family Resource Centre
Teach na Daoine Family Resource Centre

Co Offaly

Family Resource Centre
Clara Family Resource Centre
Arden View Family Resource Centre

Co Roscommon

Family Resource Centre
Family Life Centre

Co Sligo

Family Resource Centre
Ballymote Family Resource Centre
West Sligo Family Resource Centre
Sligo Family Centre
Tubbercurry Family Resource Centre

Co Tipperary

Family Resource Centre
Spafield Family Resource Centre
Three Drives Family Resource Centre Ltd
Millennium Family Resource Centre

Co Waterford

Family Resource Centre
Sacred Heart Family Resource Centre
St. Brigid's Family & Community Centre

Co Westmeath

Family Resource Centre
Cara Phort Family Resource Centre
Monsignor McCarthy Family Resource Centre

Co Wexford

Family Resource Centre
Gorey Family Resource Centre
South End Family Resource Centre
Taghmon Family Resource Centre
Raheen Family Resource Centre


Co Wicklow

Family Resource Centre
Greystones Family Resource Centre

Source: http://www.tusla.ie/uploads/content/FSA_NEW_VERSION_of_FRC_TUSLA_website_28th_Jan.pdf