Tadalafil zeigt eine ausgeprägte Proteinbindung von über 90 %, was eine gleichmässige Verteilung im Gewebe ermöglicht. Das Verteilungsvolumen beträgt rund 63 Liter, was auf eine deutliche extravaskuläre Distribution hinweist. Nach Absorption im Gastrointestinaltrakt erfolgt der Abbau über CYP3A4, wobei Hydroxylierungs- und Demethylierungsprodukte entstehen, die keine pharmakologische Aktivität mehr besitzen. Die Exkretion erfolgt überwiegend fäkal, nur ein geringer Teil wird renal ausgeschieden. Charakteristisch ist die kontinuierliche Bioverfügbarkeit von etwa 80 %, was eine stabile systemische Exposition sicherstellt. Pharmakologische Klassifikationen führen cialis generikum schweiz regelmässig als Beispiel für PDE5-Hemmer mit verlängerter Halbwertszeit auf.
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2005 North Carolina Teachers’ and State Employees’ Comprehensive Major Medical Preferred Drug List Please bring this list with you to every doctor visit.
2005 Medco Health Solutions, Inc. All rights reserved. Medco is a registered trademark of Medco Health Solutions, Inc.
If you have questions about your prescription drug benefit,
visit www.medco.com or call Member Services. WHAT IS A PREFERRED DRUG LIST? A preferred drug list is a list of medications covered by your prescription drug plan. The North Carolina Teachers’ and State Employees’ drug list has been compiled by a committee of North Carolina physicians and pharmacists organized by the plan. It includes medications made by most pharmaceutical manufacturers and for a variety of conditions.
Using preferred medications can help you save money on your prescriptions. When you use a medicationon the preferred list, your co-payment (for up to a 34-day supply) will be:
Generic drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $10 Brand-name drugs (without a generic equivalent) . . . . . . . . . . . . . . . . . . . . . . . . . . . . $25 Brand-name drugs (with a generic equivalent) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $35 Nonpreferred brand-name drugs and other drugs as determined by the Pharmacy & Therapeutics Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $40 WHAT ARE MY CO-PAYMENTS? (Up to a 34-day supply) (35 – 68-day supply) (69 –102-day supply)
equivalent)Brand-name drugs(with a generic
equivalent)Nonpreferred brand-name drugs and other drugs as
determined by the Pharmacy& Therapeutics Committee
WHY SHOULD I USE GENERIC DRUGS? All generic drugs are preferred medications. Ask your doctor to authorize generic substitution whenever a generic alternative is available. You will save money using generic drugs, since the co-payment is $10 for a 34-day supply.
Generic drugs, like brand-name drugs, must meet established Food and Drug Administration (FDA) stan-dards of quality and purity to help ensure their safety and effectiveness. Generic versions have the exactsame active ingredients as their brand-name counterparts, and they are equal in strength and dosage. Sometimes drug manufacturers use different inactive ingredients, such as fillers and dyes, to provide adrug’s shape, color, size, and taste.
By prescribing generics and preferred brand names, your doctor can help you save money. Remember tobring this list with you each time you visit your doctor. Please note: This is not a complete list of preferred drugs. In some cases, the Plan may have certain coverage limits. Some drugs require prior authorization or may be subject to quantity limits. Refer to your benefit materials or call 1 800 336-5933 for specific coverage information. You can also refer to www.statehealthplan.state.nc.us for a complete preferred list. This list is subject to change.
The information herein was current at the time of printing and is subject to change. THERAPEUTIC DRUG CATEGORIES $35.00 Co-pay $35.00 Co-pay ANTINEOPLASTICS AND IMMUNOSUPPRESSANTS $35.00 Co-pay Miscellaneous $10.00 Co-pay $10.00 Co-pay are covered under the Rx benefit, $25.00 Co-pay $25.00 Co-pay BLOOD MODIFIERS Beta-Blockers Beta and Alpha Blockers $35.00 Co-pay $25.00 Co-pay $35.00 Co-pay Anticoagulants Myasthenia Gravis $25.00 Co-pay $10.00 Co-pay $10.00 Co-pay acebutolol CENTRAL NERVOUS SYSTEM $35.00 Co-pay $10.00 Co-pay Alzheimer’s Disease $25.00 Co-pay Parkinson’s Disease $25.00 Co-pay $25.00 Co-pay $10.00 Co-pay Blood Cell Formation $35.00 Co-pay $25.00 Co-pay Analgesics $10.00 Co-pay $25.00 Co-pay Platelet Aggregation Inhibitors $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay Calcium Channel Blockers $35.00 Co-pay $35.00 Co-pay $10.00 Co-pay Miscellaneous $10.00 Co-pay $25.00 Co-pay Seizures $10.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $10.00 Co-pay $35 Co-pay $25.00 Co-pay CARDIOVASCULAR $35.00 Co-pay $25.00 Co-pay ACE Inhibitors $10.00 Co-pay Diuretics $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay $35.00 Co-pay $35.00 Co-pay DERMATOLOGY Alpha-Blockers Acne Vulgaris $10.00 Co-pay $10.00 Co-pay Lipid-Lowering Agents $35.00 Co-pay $25.00 Co-pay $35.00 Co-pay Angiotensin II Receptor Blockers $10.00 Co-pay $25.00 Co-pay $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $35.00 Co-pay Migraine Antiarrhythmics and $25.00 Co-pay Cardiac Glycosides $10.00 Co-pay $10.00 Co-pay $35.00 Co-pay Nitrates $35.00 Co-pay $25.00 Co-pay $10.00 Co-pay Bacterial Infections $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay
2005 North Carolina Teachers’ and State Employees’ Comprehensive Major Medical Plan
THERAPEUTIC DRUG CATEGORIES (CONT.) $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay Corticosteroids $35.00 Co-pay Inflammatory Bowel Disease $10.00 Co-pay $25.00 Co-pay $10.00 Co-pay $25.00 Co-pay $10.00 Co-pay EAR, NOSE & THROAT $25.00 Co-pay $10.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay Pancreatic Enzymes $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay Growth Hormone $40.00 Co-pay $35.00 Co-pay $25.00 Co-pay $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay Miscellaneous $35.00 Co-pay $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay Depigmenting and Repigmenting Agents $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $25.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay GASTROINTESTINAL $25.00 Co-pay Diarrhea $10.00 Co-pay INFECTIOUS DISEASES $35.00 Co-pay $25.00 Co-pay Antibacterials ENDOCRINOLOGY $35.00 Co-pay $25.00 Co-pay Adrenal Corticosteroids $10.00 Co-pay $10.00 Co-pay $10.00 Co-pay $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay Gastroesophageal Reflux $25.00 Co-pay Disease (GERD) $10.00 Co-pay $10.00 Co-pay $35.00 Co-pay Diabetes Mellitus $25.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay $10.00 Co-pay Gastrointestinal Spasm $10.00 Co-pay $35.00 Co-pay
2005 North Carolina Teachers’ and State Employees’ Comprehensive Major Medical Plan
THERAPEUTIC DRUG CATEGORIES (CONT.) $35.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay $25.00 Co-pay 30 mcg estrogen Transdermal $10.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $35.00 Co-pay $35.00 Co-pay
norgestrel/EE 0.3/30 $25.00 Co-pay Progestins $10.00 Co-pay $10.00 Co-pay $35.00 Co-pay MUSCULOSKELETAL $25.00 Co-pay $35.00 Co-pay Arthritis $35.00 Co-pay Antifungals 35 mcg estrogen $10.00 Co-pay $10.00 Co-pay $10.00 Co-pay Anti-Estrogens $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay $35.00 Co-pay $35.00 Co-pay Infertility Antivirals $40.00 Co-pay $10.00 Co-pay 50 mcg estrogen $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay desogestrel/EE $25.00 Co-pay $40.00 Co-pay $35.00 Co-pay Vaginal Infections $40.00 Co-pay $25.00 Co-pay $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay $25.00 Co-pay $10.00 Co-pay $35.00 Co-pay $25.00 Co-pay $25.00 Co-pay Progestin $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay Miscellaneous $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay OPHTHALMIC $25.00 Co-pay $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $25.00 Co-pay Endometriosis $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay $35.00 Co-pay Anti-Inflammatories $25.00 Co-pay $10.00 Co-pay Hormone Therapy/Menopause $35.00 Co-pay $25.00 Co-pay $35.00 Co-pay Contraceptives Miscellaneous $10.00 Co-pay $10.00 Co-pay 20 mcg estrogen $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay
2005 North Carolina Teachers’ and State Employees’ Comprehensive Major Medical Plan
THERAPEUTIC DRUG CATEGORIES (CONT.) $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $40.00 Co-pay SUPPLEMENTS Bipolar Disorder $35.00 Co-pay $35.00 Co-pay $10.00 Co-pay Potassium $25.00 Co-pay $10.00 Co-pay RESPIRATORY DRUGS Asthma/COPD $35.00 Co-pay Infections Depression $10.00 Co-pay $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay $25.00 Co-pay $25.00 Co-pay Vitamins and Minerals $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay UROLOGICAL $35.00 Co-pay $35.00 Co-pay $25.00 Co-pay Symptomatic Benign Prostatic Hypertrophy Glaucoma $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $10.00 Co-pay $10.00 Co-pay Insomnia $25.00 Co-pay $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay Miscellaneous Narcolepsy $10.00 Co-pay $10.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay $10.00 Co-pay $25.00 Co-pay Miscellaneous $10.00 Co-pay Obsessive Compulsive Disorder $25.00 Co-pay $10.00 Co-pay $25.00 Co-pay Antitussives, Decongestants, and $35.00 Co-pay $35.00 Co-pay Expectorants $25.00 Co-pay $10.00 Co-pay PSYCHIATRIC $35.00 Co-pay MISCELLANEOUS $10.00 Co-pay Panic Disorder Anaphylaxis Emergency $10.00 Co-pay $25.00 Co-pay Hyperphosphatemia $25.00 Co-pay $25.00 Co-pay $25.00 Co-pay $35.00 Co-pay $35.00 Co-pay $40.00 Co-pay $25.00 Co-pay Premenstrual Dysphoric Disorder $25.00 Co-pay $25.00 Co-pay Attention Deficit Hyperactivity $35.00 Co-pay Disorder Psychosis $10.00 Co-pay $10.00 Co-pay Smoking Deterrents $10.00 Co-pay $35.00 Co-pay
2005 North Carolina Teachers’ and State Employees’ Comprehensive Major Medical Plan
Personal Information Form Medical History/Prophylaxis Information First Name, Last Name / / Age: / / Age: Age: Yes No Yes No Yes No Yes No (Accutane) or Acitretin (Soriatane)? Taking Theophylline For additional family members or other persons, please turn page over. Do Not Write Below this Box Ciprofloxacin Ciprofloxacin Ciprofloxacin Cip
Department of Chemistry: Part III Project 2011/2012 Prof. S. Balasubramanian Embedding Crosslinking Agents within G-4 Ligands: “An Old Strategy for a New Purpose” EMAIL sb10031@cam.ac.uk Group web site http://www-shankar.ch.cam.ac.uk/ Contact details: Dr Marco di Antonio, md530@cam.ac.uk Guanine rich oligonucleotides are capable of self-organization into sec